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© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Abstract Background:Amyloid-β (Aβ) has long been considered as one of the most important pathogenic factors in Alzheimer's disease (AD), but the specific pathogenic mechanism of Aβ is still not completely understood. Main body of the abstract:In recent years, the development of structural biology technology has led to new understandings about Aβ molecular structures, Aβ generation and clearance from the brain and peripheral tissues, and its pathological toxicity. The purpose of the review is to discuss Aβ metabolism and toxicity, and the therapeutic strategy of AD based on the latest progress in molecular structures of Aβ. Conclusion:The Aβ structure at the atomic level has been analyzed, which provides a new and refined perspective to comprehend the role of Aβ in AD and to formulate therapeutic strategies of AD.

Details

Title
Based on molecular structures: Amyloid-β generation, clearance, toxicity and therapeutic strategies
Author
Yang, Hai; Li, Jinping; Li, Xiaoxiong; Ma, Linqiu; Hou, Mingliang; Zhou, Huadong; Zhou, Rui
Section
REVIEW article
Publication year
2022
Publication date
Aug 31, 2022
Publisher
Frontiers Research Foundation
e-ISSN
1662-5099
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2708656600
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.