Ocular Inflammation Induced by Immune Checkpoint Inhibitors

Abstract

Ocular immunotherapy-related adverse events (IRAEs), although rare, can be sight-threatening. Our objective was to analyze ocular IRAEs diagnosed in France from the marketing of immune checkpoint inhibitors (ICPIs) until June 2021 and to review the literature. We collected the cases of 28 patients (36 ocular IRAEs), occurring after an average of 17 weeks (±19). Forty-six percent of patients were treated for metastatic melanoma. Anti-PD1 agents were responsible for 57% of the IRAEs. Anterior uveitis was the most common (44%), followed by panuveitis (28%). Of 25 uveitis cases, 80% were bilateral and 60% were granulomatous. We found one case with complete Vogt-Koyanagi–Harada syndrome and one case of birdshot retinochoroidopathy. The other IRAEs were eight ocular surface disorders, one optic neuropathy, and one inflammatory orbitopathy. Seventy percent of the IRAEs were grade 3 according to the common terminology of AEs. ICPIs were discontinued in 60% of patients and 50% received local corticosteroids alone. The literature review included 230 uveitis cases, of which 7% were granulomatous. The distributions of ICPIs, cancer, and type of uveitis were similar to our cohort. Ocular IRAEs appeared to be easily controlled by local or systemic corticosteroids and did not require routine discontinuation of ICPIs. Further work is still warranted to define the optimal management of ocular IRAEs.

1. Introduction

There are currently 10 immune checkpoint inhibitors (ICPIs) approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [1,2,3]. Each ICPI targets one of four checkpoints (receptors or ligands): Programmed cell Death 1, PD-1 (pembrolizumab, nivolumab, cemiplimab, dostorlimab, and prolgolimab), Programmed cell Death Ligand 1, PD-L1 (atezolizumab, durvalumab, avelumab), cytotoxic T-lymphocyte-associated protein 4, CTLA-4 (ipilimumab), and LAG3 (relatlimab). ICPIs mobilize the immune system to recognize and eliminate tumoral cells [4,5,6]. Since their first use in metastatic melanoma in 2011, they have been evaluated and validated in a growing number of indications, including non-small cell lung cancer, urothelial carcinoma, lymphoma, and clear cell renal cell carcinoma [1].

ICPIs overcome T-cell inhibition to promote tumor cell elimination [4,5]. This results in a loss of immune homeostasis and a facilitation of the inflammatory response. Thus, ICPIs can lead to autoimmune/inflammatory manifestations, remote from the neoplastic site, called immune-related adverse events (IRAEs). IRAEs vary in severity and can involve any organ, but most commonly affect the gastrointestinal tract, followed by the liver, skin, and endocrine system [7]. IRAEs affect 70 to 90% of ICPI-treated patients [8], [9]. Much less frequent, IRAEs affecting the eye have been reported with a frequency ranging from 0.2 to 7.6% [10,11,12,13,14,15,16]. This rarity explains why ocular IRAEs are poorly characterized. Yet, a wide variety of eye disorders have been reported [17,18,19,20] and can be classified into four groups: (i) ocular surface disorders (dry eye disease, blepharitis, conjunctivitis, episcleritis, scleritis, keratitis), (ii) orbital disorders (orbital inflammation, myopathy, and apex syndrome), (iii) uveitis, and (iv) optic neuropathy [21].

While early data came from case reports or small case series [22,23,24,25,26,27], more recent papers are represented by large database analysis [10,14,17,19,20,28,29,30] which include a significant number of cases but do not have a sufficient level of detail to analyze the different eye disorders and their management. The aim of our study was therefore to describe ICPI-induced ocular IRAEs, more specifically the uveitis inflammatory involvement type, detailing the anatomical specificities, potential risk factors, management, and outcome, in relation to the outcome of the underlying tumor.

2. Materials and Methods

2.1. Case Identification and Collection

Patients developing ICPI-induced ocular IRAEs were identified through multiple electronic calls for observations to practitioners belonging to (i) the French Society of Ophthalmology (SFO), (ii) the French Society of Internal Medicine, and iii) the French Eye and Internal Medicine Club. Some patients were recruited via the prospective REISAMIC registry (Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie) which was reported previously [16]. REISAMIC is a pharmacovigilance registry which only records grade ≥2 IRAEs and was initiated in June 2014. The study period in REISAMIC was from 1 January 2014 to now. The last case inclusion was in June 2021 and the data export was made in July 2021.

Patients were included if they were aged ≥18 years, and had received an ICPI to treat a solid tumor or hematological malignancy. Patients with concurrent chemotherapy or radiotherapy were not excluded. The diagnosis of ocular involvement had to be confirmed by an ophthalmologist. Patients underwent comprehensive ophthalmologic assessment, as well as ocular and orbital imaging at the discretion of the ophthalmologist. Patients with previous history of ocular disease, with a differential diagnosis (including infections and localized malignancy), or with missing data regarding the type of immunotherapy and ophthalmological description of the IRAE were excluded from the analysis.

For each patient, data were collected from medical records and biological software using an anonymous and standardized electronic Case Report Form (2016 Ennov Clinical, CSOnline v.7.5.720.1, Ennov, Olivier PARIS, Paris, France). Epidemiologic data, medical history, clinical, biological, and imaging data at the time of diagnosis and during the follow-up were collected. Cancer history, neoplastic and ophthalmologic evolution, and treatments received were also recorded.

2.2. Literature Review

The literature review was based on a search for articles that were published before the 31 December 2021. The following PubMed search strategy was performed using the terms (“checkpoint inhibitor” OR “immunotherapy” OR “immune checkpoint inhibitor” OR “ipilimumab” OR “pembrolizumab” OR “nivolumab” OR “atezolizumab” OR “durvalumab” OR “avelumab”) AND (“ocular adverse events” OR “ophthalmologic event” OR “uveitis” OR “VKH (Vogt-Koyanagi-Harada)”). Articles were limited to the English language. Reviews were used to identify potential eligible articles. For uveitis case reports, extracted data included study characteristics (author, publication year), patient demographics (gender, age, cancer type), intervention (ICPI name, potential associated therapies), ophthalmologic outcome (timing of occurrence, evolution), extra-ophthalmologic features (cutaneous, neurological features, neoplastic evolution), and medical care.

2.3. Definitions

We used the Standardization of Uveitis Nomenclature (SUN) criteria to classify uveitis [31]. Persistent ocular inflammation corresponded to persistent inflammatory activity at the last ophthalmological visit. Signs of inflammatory activity were the presence of anterior chamber cells (Tyndall), vitreous haze or vitritis, active retinitis on fundus, retinal vasculitis on angiography. The severity of IRAEs was graded according to the common terminology criteria for adverse events [32], version 5.0, November 2017. The diagnostic criteria used were:

• The Levinson’s criteria [33] or the global diagnostic criteria for birdshot retinochoroidopathy.

• The international criteria for the diagnosis of sarcoidosis [34]. In the absence of histological proof, we used Abad’s modified criteria [35]. Patients had presumed sarcoid uveitis if they had at least 2 of the following 4 criteria: typical changes on chest X-ray or CT-scan, a predominantly CD4 lymphocytosis on bronchioalveolar fluid analysis, an elevated ACE, or an 18-fluorodeoxyglucose (18-FDG) uptake on scintigraphy. They had indeterminate sarcoid uveitis when only one criteria was met.

• The revised diagnostic criteria for VKH disease [36]. Complete VKH has to meet the following five diagnostic criteria: (i) absence of history of penetrating ocular trauma, (ii) absence of other ocular disease entities, (iii) bilateral ocular involvement, (iv) neurological/auditory findings, and (v) alopecia, vitiligo or poliosis.

2.4. Statistical Analysis

Descriptive analyses are presented as medians (interquartile range, IQR) for non-normally distributed continuous variables and as frequencies and percentages for categorical variables. Patient anonymity was maintained throughout the data collection and statistical analysis phases. All analyses were performed using the statistical software RStudio, v1 3.1093. (R foundation for Statistical Computing, Vienna, Austria).

2.5. Ethics

This noninterventional study was conducted in compliance with good clinical practice and the tenets of the Declaration of Helsinki. This study has been authorized by the French National Data Protection Commission (CNIL, Commission Nationale de l’Informatique et des Libertés, Paris, France) and registered under the number 19-157. All patients indicated their non-opposition to the study. Constitution of the REISAMIC registry had been authorized by the French National Data Protection Commission (Commission Nationale de l’Informatique et des Libertés).

3. Results

3.1. Characteristics of the Study Population

We identified 28 patients who developed ICPI-induced ocular IRAEs. Their age, gender, type of cancer, and ICPI are available in Table 1. The mean age was 59.4 years (standard deviation (SD): 12.2 years) and ranged from 36 to 80. There was no significant age difference by ICPI type. The men-to-women ratio was 1.5.

Seven patients had an ocular medical history: six non-inflammatory ophthalmological histories (two cataracts, one chronic open angle glaucoma, one retinal detachment, one epimacular membrane and one blepharospasm) and one untreated uveitis under dabrafenib, a MAPK inhibitor (patient #11).

Thirteen patients (46.4%) were treated for malignant melanoma, including one for uveal melanoma, six (21.4%) for lung adenocarcinoma, three (10.7%) for pulmonary squamous cell carcinoma, three (10.7%) for a clear cell renal cell carcinoma, one (3.5%) for parotid adenocarcinoma, one (3.5%) for pleural mesothelioma and one (3.5%) for urothelial cancer. All patients had metastatic cancer at the time of ICPI treatment, except for one patient with unresectable squamous cell lung cancer and two patients with unknown metastatic status.

As reported in Figure 1, 16 patients (57%) were treated with an anti-PD-1 monotherapy. Eight (28%) patients were on combination therapy of ipilimumab and nivolumab, one (4%) on atezolizumab, two (7%) on durvalumab and one (4%) was treated with ipilimumab prior to pembrolizumab. One patient treated by nivolumab in January 2018 (i.e., 3 months before she developed uveitis) had been treated with ipilimumab in 2011 and pembrolizumab in 2015 without ocular IRAEs.

3.2. ICPI-induced Ocular IRAEs

There were 36 ocular IRAEs among the 28 patients, yielding an average of 1.28 events per patient (Table 2). The mean time to occurrence of all IRAEs combined was 17.6 (±19) weeks. Twenty-one (88%) patients had bilateral involvement at the time of diagnosis. The most common disease was uveitis, with 25 cases present in 22 patients. Eight patients (29%) had ocular surface disorders. Optic neuropathy and orbitopathy were present in one case each (2.8%).

3.2.1. Uveitis

Of the 36 ocular disorders collected, 25 (69.4%) were uveitis, reported in 22 patients (Table 3).

The anatomical distribution of uveitis according to ICPI type is shown in Table 2 and Figure S1 in Supplementary Materials. Anterior uveitis was the most common (n = 11), followed by panuveitis (n = 7), intermediate uveitis (n = 4), and posterior uveitis (n = 3). Twenty (80%) uveitis were bilateral. Of the 18 uveitis cases involving the anterior segment, 12 (66%) were granulomatous: five had mutton fat keratic precipitates, two had iris nodules, and five had granulomatous features without further details in medical charts. There were six uveitis with synechia, one hypertensive anterior uveitis, one hypertensive posterior uveitis, and one hypertensive panuveitis. All posterior uveitis were chronic and bilateral. One patient had peripheral multifocal choroiditis and papillary edema. One patient had macular edema and one patient had retinal vasculitis.

Patient #9 had bilateral anterior uveitis associated with multiple white spots on the posterior pole. The clinical picture was compatible with a VKH-like uveitis. No long after, she presented with vitiligo, and lymphocytic meningitis, completing the criteria for VKH syndrome.

Three patients had extra-ocular and ocular involvement that suggested a diagnosis of sarcoidosis or birdshot uveitis, for which the diagnostic criteria were not met:

• Patient #1 presented with bilateral acute granulomatous and synechial anterior uveitis associated with acute intermediate uveitis. She had concomitant hypercalcemia and mediastinal and cervical adenopathy, raising suspicion of sarcoid uveitis. The cervical lymph node biopsy finally revealed metastatic progression of melanoma despite treatment with durvalumab, leading to its discontinuation.

• Patient #22, who presented with posterior uveitis underwent mediastinal lymphadenopathy biopsy, showing chronic adenitis without evidence of sarcoidosis or tuberculosis.

• Patient #17, positive for the HLA-A29 antigen, had multifocal choroiditis and optic nerve swelling, without retinal vasculitis, leading to a diagnosis of birdshot-like retinochoroidopathy.

Fourteen (70%) patients had CTCAE grade 3, i.e., anterior uveitis with 3+ or greater cells, intermediate uveitis, posterior uveitis, or pan-uveitis. Three (15%) patients had anterior uveitis with 1+ or 2+ cells corresponding to a grade 2. There was insufficient data regarding the severity of the eye involvement in 3 cases.

Four patients had other ocular features associated with uveitis: two had scleritis, one did have acute anterior ischemic optic neuropathy and one suffered a dry eye syndrome.

3.2.2. Other Ocular Manifestations

Six (21%) patients had non-uveitic ocular IRAEs, reported in Table 4.

Patient #25 had a perforated corneal ulcer in the context of Sjögren’s syndrome, confirmed by salivary test. The biopsy of minor accessory salivary glands showed borderline histological criteria, without focus; anti-nuclear antibodies were positive (titer, 1/160) without antigen specificity. Despite the discontinuation of nivolumab and local treatment with corticosteroids (eye drops and injections) and oral ciclosporin, he presented repeated rejections of corneal grafts. The histology performed on the enucleation material revealed keratitis with hyperplastic and atrophic areas of the corneal epithelium, intense edema, and neutrophilic infiltrate of Bowman’s membrane stroma. Reactive gliosis was found within the retina and ciliary bodies.

Of the two cases with keratoconjunctivitis, one (the only patient treated with atezolizumab) was complicated by conjunctival fibrosis.

No ocular surface involvement was found in patients treated by nivolumab + ipilimumab.

Patient #28 had orbital myositis with complete ophthalmoplegia and mydriasis, associated with myocarditis. Myositis-specific antibodies (anti-t-RNA synthetase, anti-MDA-5, anti-TIF1-γ, anti-Mi2, anti-SAE, anti-NXP2, anti-SRP, and anti-HMGCR antibodies), and anti-acetylcholine receptors antibodies were absent. Discontinuation of pembrolizumab and administration of three pulses of i.v. corticosteroids, followed by two courses of i.v. immunoglobulins and methotrexate allowed recovery.

3.2.3. Concomitant Extra-Ocular ICPI-induced IRAEs

Seventeen extra-ocular ICPI-induced IRAEs were reported. The most frequent was vitiligo (n = 4), followed by central or peripheral neurological involvement (lymphocytic meningitis, hypertensive meningitis, peripheral neuropathy, cochlear neuritis). The other reported IRAEs were varied and involved one patient each: hepatitis, pancreatitis, colitis, interstitial nephritis, myositis, hypophysitis, hypothyroidism, myocarditis, and lichen planus. One patient (#9) had multiple extra-ocular IRAEs, which were consistent with the diagnosis of a VKH-like syndrome.

3.3. Management

The details of ocular management are shown in Table 5. ICPIs were discontinued in 17 (60%) patients, either because of ocular or extra-ocular IRAEs. Three (10%) patients did not receive any specific treatment to treat ocular IRAEs. Nine (32%) patients received only local steroids, while 14 (50%) received systemic steroids; 11 of them (39%) received both. Two patients (#17 and #21) received oral steroids for an extra-ocular indication (pancreatitis and colitis).

3.3.1. Management of ICPI-Induced Uveitis

Thirteen (52%) patients stopped ICPIs after the diagnosis of uveitis (Table 6). In addition to these 13 patients, three (12%) patients under ipilimumab/nivolumab combination therapy discontinued only one of the two ICPIs (ipilimumab). Fifty-four percent of these 16 patients received systemic steroids. Six of the seven patients with panuveitis required systemic steroids. One patient (#15) required several additional immunosuppressive therapies (i.e., methotrexate, abatacept, infliximab, and alpha interferon). Patients #3 and #14 did not receive any specific treatment for ICPI-induced uveitis.

3.3.2. Management of Other Ocular IRAEs

The two patients with keratitis (#25 and #26) and the one with bilateral orbitopathy (#28) required systemic steroids. In addition, patient #28 received methotrexate and i.v. immunoglobulins. Patient #25 was enucleated after seven corneal graft rejections. The three other ocular surface IRAEs were treated with topical steroids.

3.4. Outcome

3.4.1. Ophthalmological Outcome

At the end of the follow-up (13.2 months (±11)), 12 (43%) patients had complete ophthalmological remission and 10 (36%) had partial remission. Only one patient (patient #25) had a worsening ocular disorder. Outcome data were not available for three (10%) patients.

Specifically, the ophthalmological course of uveitis is shown in Figure 2 and detailed for each patient in Table 5. Eighteen (81%) patients had a partial or complete response to treatment. The evolution was unknown for two patients with anterior uveitis. No patient had a worsening of their uveitis at the end of the follow-up. Among the three patients with posterior uveitis, two (66%) patients had partial remission and one (33%) had complete remission. Two (9%) patients had stable uveitis despite treatment: one patient (#6) with subconjunctival steroids, the other (#15) with combinations of intravitreal, topical and i.v. steroids plus other immunosuppressants.

3.4.2. Neoplastic Outcome

Neoplastic evolutions are described in Table 5 and depicted in Figure S2. At the end of the follow-up, nine (32%) patients had stable underlying neoplasia. Ten (36%) patients were in remission, of which seven had a complete remission (five with metastatic melanoma and two with pulmonary adenocarcinoma). ICPIs were maintained in three of these seven patients. Four (14%) patients experienced progression of their neoplastic disease. Among these four patients, ICPIs were discontinued in all four and two received systemic steroids. The neoplastic evolution is unknown for five (18%) patients, but all those with available data, were alive at the last follow-up.

4. Literature Review

We identified 84 articles reporting case reports or case series of patients with ICPI-induced ocular IRAEs. Of the 230 reported cases, 143 (62%) had uveitis. Table 7 summarizes the nature of ICPI, the type of uveitis and its management, as well as the outcome of the underlying neoplasm. The mean age at the time of ICPI-induced uveitis was 60.1 (±9.5) years. The men-to-women ratio was 1.9.

The most common uveitis were anterior uveitis (43%) and panuveitis (37%). Of note, half of the patients with panuveitis had features of VKH-like uveitis. Posterior uveitis was the less frequent anatomical type (n = 28, 19%).

A total of 96 (67%) patients were treated for metastatic melanoma, followed by non-small-cell lung cancer (13%, 18/143) and renal cell carcinoma (8%, 12/143) (Figure S3). All cancers were metastatic.

Overall, 76% (109/143) of patients had bilateral uveitis, up to 82% (51/62) in patients with anterior uveitis (Figure S4). Granulomatous involvement was described in only 10 (7%) cases, including five anterior uveitis, one posterior uveitis and four VKH-like uveitis. 22% of uveitis cases were graded 1 or 2 in severity, while 68% were grade 3 or 4. The mean time between ICPI introduction and uveitis diagnosis was 16.8 (±20.3) weeks. Of note, four patients (3%) who had undergone enucleation for the treatment of a uveal melanoma had ICPI-induced uveitis on the remaining eye.

In 88 (61%) uveitis cases, ICPIs were stopped after the onset of uveitis (Figure S5a). ICPIs were most frequently discontinued when patients developed posterior uveitis (n = 23/28, 82%).

In all, 36 (58%) of the 62 anterior uveitis cases were treated with local steroids only (Figure S5b). Among the 26 panuveitis cases, 11 (42%) received only local steroids, and 9 (35%) were treated with a combination of topical and systemic steroids.

Nivolumab was the most frequent ICPI reported in anterior uveitis (30.6%), VKH-like uveitis (37%), and all types of uveitis (28.6%) (Table S1). In contrast, pembrolizumab was associated with 32.1% of posterior uveitis and 50% of panuveitis.

Twenty-seven VKH/VKH-like uveitis cases were reported (Table 8) and subdivided into four categories. Melanoma was the most frequently treated cancer (n = 19, 70%), followed by non-small cell lung cancer (14%).

Anti-PD1 agents were reported in 77% of patients developing VKH-like uveitis: mostly nivolumab (37%) and pembrolizumab (29%) monotherapies (Table S1). In 11% of the cases, VKH-like syndrome occurred during ipilimumab/nivolumab combined treatment.

Overall, 85% of patients received systemic steroids and ICPI were discontinued in 52% of patients (Figure S5).

5. Discussion

This study adds 28 new cases of ocular IRAEs induced by ICPIs. Overall, these new cases were similar to those previously reported [14,16,22,25,26,37,41,50]. Indeed, most patients were aged around 60 years, with an overrepresentation of males (ratio = 1.9). Such findings are representative of the epidemiology of cancers treated by ICPIs: melanoma and lung cancers [110,111]. Indeed, almost half of patients had melanoma, which was the first approved indication for ICPIs [13,112], and has already been reported in a previous series [10,11,19,29]. The literature review was also consistent with these findings. Yet, some authors have suggested an alternative hypothesis: melanoma itself would constitute a risk factor for ocular IRAEs, particularly for uveitis [11,26]. This hypothesis is supported by the known relationship between melanoma and ocular disorders or ocular IRAEs [13,14,23,113,114,115,116,117,118,119,120,121,122,123], which seem more frequent in patients treated for melanoma than those treated for other neoplasms. Given these data, one could recommend that symptoms suggestive of ocular-IRAEs should be repeatedly assessed in patients treated with ICPIs for melanoma.

All types of ICPIs were used in our cohort, but none of our patients was treated with ipilimumab as monotherapy. Previous reports have suggested that anti-CTLA-4 could cause more frequent and more serious IRAEs than anti-PD-1 and anti-PD-L1 [124,125,126]. There is no clear explanation for such findings, which remain to be consolidated but previous systematic reviews and meta-analyses have ranked the general safety of ICPIs from low to high as: ipilimumab < pembrolizumab < nivolumab < atezolizumab [127]. In Fang’s study, the anti-CTLA4, ipilimumab had the highest association with uveitis [28] but this finding was conflicting with that of Hou et al., who did not find excess risk for anti-CTLA-4 over anti-PD-1 [128] when looking at all-types ocular IRAEs. As of today, data remain scarce and ICPI prescription is heterogeneous (i.e., anti-PD1 being the most frequently prescribed), precluding definitive conclusions [14,28].

Almost 80% of ocular IRAEs occurred within the first six months after ICPI introduction, which was consistent with the literature [17,27]. Clinicians should thus be aware that ocular IRAEs occur early after ICPI initiation, and alerting symptoms should be explained to patients. As of today, one cannot recommend systematic ophthalmological monitoring since most ocular IRAEs were mild to moderate and treatment-sensitive. However, some late-onset ocular IRAEs have been reported, even after ICPI discontinuation [17]. Information about past ICPI intake should therefore be an integral part of the questioning of ophthalmologists in patients with a history of cancer and unexplained ocular inflammation.

In our series, almost half the anterior uveitis cases occurred in the setting of nivolumab and or ipilimumab/nivolumab, the combination of which has already been associated with increased rates of anterior uveitis [17]. Bomze et al. have already reported that the addition of an anti-CTLA-4 to an anti-PD1 increases the risk of uveitis, as well as optic nerve disorder and lacrimal disorders [13].

Our study reports a significant number of IRAEs occurring during anti-PD-L1 treatment. This was more rarely reported in the literature, which contains 14 observations of ocular IRAEs under anti-PD-L1, of which seven were uveitis. One explanation is that anti-PD-L1 were the most recently approved and still have limited indications. Interestingly, a significantly higher incidence of posterior uveitis has been described with atezolizumab [17], with some cases of acute macular neuroretinopathy or paracentral acute middle maculopathy with retinal vasculitis [17]. We did not observe such findings in the three patients with posterior uveitis.

Consistent with the literature, uveitis was the most commonly reported IRAE and was bilateral in most cases [17,29,41]. Half of the uveitis were anterior, a frequency that has been reported between 30 and 75% in previous studies [12,13,17,26]. While the majority of our cases of anterior uveitis had granulomatous features, non-granulomatous uveitis predominated in other studies [27,29]. This discrepancy is difficult to analyze but may result from the lack of detailed description of uveitis in case series and case reports.

VKH-like syndromes and VKH-like uveitis seem to have a dedicated place in ocular IRAEs, representing almost half of the panuveitis cases reported in the literature. In their literature review, Dow et al. found that 35% of ICPI-induced panuveitis were VKH-like, suggesting a specific entity [17]. Pathophysiologically, a disruption of the balance between tumor cell killing and immune tolerance to melanocytes has been hypothesized. Similar to our patient, most published cases with ICPI-related VKH-like syndrome had skin involvement 2 to 4 weeks after the first dose of ICPI. This contrasts with typical VKH syndrome in which skin signs occur several weeks or months after the first symptoms (i.e., headaches, uveitis). Most ICPI-related-VKH cases occurred in patients treated for metastatic melanoma, and a few in patients with lung cancer. The relationship between melanoma and VKH-like uveitis is thought to be due to cross reactivity of normal choroidal melanocytes and malignant melanoma cells [129,130], in patients with a possible HLA-related genetic predisposition [131]. Interestingly, the development of VKH has been proposed as a clinical sign suggesting better ICPI efficacy [132]. The complete neoplastic remission of patient #9 is in line with this hypothesis.

Two other phenotypes of ICPI-induced uveitis have been reported: sarcoidosis-like uveitis and birdshot-like chorioretinopathy. Regardless of the ocular involvement, ICPIs may induce other systemic sarcoidosis-like reactions, affecting lymph nodes, lungs or skin [133]. Yet, a history of sarcoidosis does not contraindicate ICPIs [50], and the management is similar to that of sarcoidosis. ICPI discontinuation should only be discussed in case of severe or refractory involvement, and after a careful multidisciplinary evaluation [134]. Neoplastic progression should always be sought as a differential diagnosis (e.g., in case of progressive lymphadenopathy, uveal melanoma).

One patient in our series had birdshot-like chorioretinopathy. This is the second report of such a presentation [84] and both patients received anti-PD-1 in the setting of metastatic melanoma. However, only our patient was positive for the HLA-A29 antigen. It is thus impossible to conclude that HLA-A29 may predispose to ICPI-induced birdshot-like uveitis, nor if the absence of this antigen is sufficient to rule out the diagnosis. Further studies are needed, one axis of which should be the assessment of the predisposing role of the HLA system in ICPI-induced IRAES mimicking HLA-related immune diseases.

Although they were the second most frequently reported ICPI-induced ocular IRAEs, ocular surface disorders may have suffered reporting bias. Indeed, most of the less invalidating ocular IRAEs (e.g., dry eye, conjunctivitis) may have been underreported, and only severe cases (e.g., keratitis) may have been recorded. In accordance, no isolated dry eye syndrome was recorded, whereas this was the most common ocular side-effect in pivotal RCTs (incidence range, 1.2–24% [8,14,18]. Various ocular surface disorders have been reported, with all ICPIs. Fortunately, most resolved or were controlled with topical treatment (lacrymal substitutes and/or steroid eye drops) [14,23,120,122]. In very rare cases of ulcerative keratitis or corneal perforation, ICPI had to be discontinued [23,122,123,135]. Interestingly, different histological patterns were found in patients with ICPI-induced sicca syndrome compared to patients with Sjögren’s syndrome: increased number of CD3+ T cells, a slight predominance of CD4+ compared with CD8+ T cells, and a paucity of CD20+ B cells in contrast with the immune cell infiltrates of Sjögren’s syndrome [136].

Bilateral papillitis occurred in one patient with aseptic hypertensive meningitis, and was followed by an acute anterior ischemic optic neuropathy. Bilateral non-arteritic ischemic optic neuropathy has been previously reported in only one patient under nivolumab [50] but optic neuritis has been reported in several patients, under various ICPIs (mostly ipilimumab) [137]. Of note, ICPI-associated optic neuritis may present in a more atypical fashion than that associated with multiple sclerosis, with 90% of painless visual loss and/or floaters without vitreous pathology and bilateral optic nerve involvement in 64% [138]. No cases reported the presence of anti-MOG nor anti-aquaporine-4 antibodies.

In our series, as well as in the literature review, most ocular IRAEs were graded CTCAE 3 or 4, whereas in larger studies or RCTs, they were mainly described as mild [9,132]. Here again, there might have been a reporting/publication bias, capturing the most severe cases. Nevertheless, these are the cases more prone to require thorough medical evaluation and systemic treatment.

Most anterior uveitis were treated with topical treatment alone, with a positive outcome [16,19,22,25,26,27,38,41,44,45,48,52,59,63,102]. In the literature, uveitis recurrences have mainly been noted when patients resumed ICPI [17,61] sometimes with a different SUN anatomical classification. In addition, uveitis recurrence was frequently more severe than the first episode. Posterior uveitis were often treated and controlled by steroid intravitreal injections or vitreous implants [22,25,51,64,76,81,103].

ICPIs were discontinued in most patients with ocular IRAEs. The frequency of low grade toxicities, along with the favorable outcome with minimal treatment in most patients, should lead to a reconsideration this attitude, since ICPI discontinuation may not be required in mild to moderate of the cases. The 2019 ASCO guidelines recommended to continue ICPI in cases of grade 1 toxicities, and prescribe artificial tears, as well as referring patients to ophthalmologists within one week [126]. For grade 2 toxicities, they advised to hold ICPI until an urgent ophthalmology referral, and then to administer either topical steroids, cycloplegic agents and/or systemic steroids. Grade 3 and 4 toxicities require definitive ICPI discontinuation, an urgent ophthalmology referral and systemic plus topical steroids; infliximab may be discussed in severe and/or refractory cases [126]. Finally, a multidisciplinary evaluation of the risk/benefit ratio, with experimented oncologists and ophthalmologists, followed by a close monitoring should guide the management of these patients [26].

The limitations of our study include the limited sample size, the retrospective design, and the reporting bias intrinsic to studies based on a call for observations. However, while we have certainly captured the most severe cases, these are the most important ones (i.e., those requiring medical evaluation and management). The design of our study did not allow determining the prevalence of ocular IRAEs. Yet, our study provides detailed case descriptions. Finally, we were not able to collect the doses and administration schemes of ICPIs, precluding the assessment of a dose-dependent effect [28]. Larger cohort studies, such as registries and post-marketing analyses, are needed to better inform clinicians and patients on ICPI-induced ocular IRAEs, mostly regarding their prediction, prevention, and detection, as well as their optimal management.

6. Conclusions

Although it captured mostly severe cases, our study is one of the largest reportingl ICPI-induced ocular IRAEs in detail. We note the predominance of anterior uveitis, with an interesting proportion of granulomatous uveitis in our cohort. In addition, uveitis as part of a VKH syndrome is frequently reported with ICPIs and may be an interesting lead for understanding this disease as well as the immunological mechanism of ocular IRAEs. The treatment of ocular IRAEs was mostly simple, with topical treatments, reflecting the high prevalence of anterior segment involvement. Most of the time, ICPIs were discontinued, but this likely reflects a practice that predates the 2019 recommendations and discontinuation of ICPIs is likely no longer warranted. A multidisciplinary approach is required for the management of these patients. Larger studies will soon help us to define the optimal management of these IRAEs.

Author Contributions

Conceptualization, F.C., Y.J. and P.S.; methodology, Y.J.; formal analysis, F.C.; investigation, F.C., A.R., A.T.J.M., P.F., P.L., J.K., M.S., R.M., B.G., S.T., H.M., P.-A.Q., S.D., O.L. and L.K.; writing—original draft preparation, F.C. and Y.J.; writing—review and editing, F.C., Y.J., A.R., A.T.J.M., S.T. and O.L.; visualization, F.C.; supervision, Y.J. and P.S.; funding acquisition, Y.J. All authors have read and agreed to the published version of the manuscript.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Hospices Civils de Lyon. Ethical approval has been obtained from the French CNIL (#19-157).

Informed Consent Statement

All patients were sent written information about the study. In accordance with French legislation on non-interventional retrospective studies, no written informed consent was required for inclusion.

Data Availability Statement

All data relevant to the study are included in the article or uploaded as Supplementary Materials. Additional data may be obtained on reasonable request from the corresponding author.

Acknowledgments

The authors thank Sylvie Thevenon for handling the eCRF and Nora Martel for her assistance throughout the study. The authors thank Christelle Schneider, Vincent Daïen, and Rahima Ziane for their contribution to this work.

Conflicts of Interest

P.S. declared conflicts of interest from Novartis, Abbvie, GSK, UCB Pharma, Lilly, and Chugai. A.T.J.M. declared speaking fees from Astra-Zeneca, Sanofi-Aventis, MSD, and BMS in the last 5 years. S.D. received research grants from MSD, Roche, and BMS; his spouse is Sanofi employee. O.L. reported links of interest with MSD, AstraZeneca, AbbVie and BMS. L.K. declared conflicts of interest from Abbvie, Alimera, Horus, Bayer, Novartis, Roche, and Thea.

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures and Tables

Figure 1. Distribution of ICPIs.

Figure 2. Ocular outcomes depending on the type of uveitis, in %.

Table 1

Characteristics of patients with ICPI-induced ocular IRAEs.

	All ICPIs(n = 28)	Nivolumab(n = 9)	Pembrolizumab(n = 7)	Nivolumab + Ipilimumab(n = 8)	Nivolumab then Pembrolizumab(n = 1)	Durvalumab(n = 2)	Atezolizumab(n = 1)
Mean age, in years (±SD)	59.4 (±12)	59.5 (±10)	66.3 (±11)	54.4 (±12)	59	59 (±12)	57
Male % (n)	60.7 (17)	55.5 (5)	85.7 (6)	50 (4)	100 (1)	50 (1)	100 (1)
Female % (n)	39.3 (11)	44.4 (4)	14.3 (1)	50 (4)	0 (0)	50 (1)	-
Indication % (n)
Melanoma	46.4 (13)	44.4 (4)	42.8 (3)	62.5 (5)	100 (1)	-	-
Lung adenocarcinoma	21.4 (6)	22.2 (2)	28.6 (2)	12.5 (1)	-	50 (1)	-
Squamous cell lung cancer	10.7 (3)	22.2 (2)	14.3 (1)	-	-	-	-
Renal cell carcinoma	10.7 (3)	11.1 (1)	14.3 (1)	12.5 (1)	-	-	-
Other	10.7 (3)	-	-	12.5 (1)	-	50 (1)	100 (1)
Mean time to occurrence in weeks (±SD)	17.6 (±19)	25 (±24)	11 (±9)	7 (±6)	65	15 (±1)	34

ICPI = immune checkpoint inhibitor; SD = standard deviation.

Table 2

Types of ocular IRAEs according to the ICPI.

	All ICPIs,n (%)	Nivolumab, n	Pembrolizumab, n	Nivolumab + Ipilimumab, n	Ipilimumab then Pembrolizumab, n	Durvalumab, n	Atezolizumab, n
All ocular IRAEs	36	13	9	8	2	3	1
Uveitis	25 (69.4%)	9	5	8	1	2	-
- Anterior	11 (30.6%)	3	1	5	1	1	-
- Intermediate	4 (11.1%)	3	-	-	-	1	-
- Posterior	3 (8.3%)	1	1	1	-	-	-
- Panuveitis	7 (19.4%)	2	3	2	-	-	-
- Bilateral	20	7	3	7	1	2	-
Scleritis	2 (5.5%)	-	1	-	1	-	-
Keratitis	2 (5.5%)	2	-	-	-	-	-
Keratoconjunctivitis	2 (5.5%)	-	1	-	-	-	1
Sjögren’s syndrome	3 (8.3%)	1	1	-	-	1	-
Optic neuritis	1 (2.8%)	1	-	-	-	-	-
Orbitopathy	1 (2.8%)	-	1	-	-	-	-

Table 3

Detailed ocular findings in patients with ICPI-induced uveitis.

	Gender/Age (Years)Neoplasia	ICPI	Ocular IRAE	B	A	G	S	Initial BCVA	Final BCVA	CTCAE Grade	Onset Time (Weeks)	Other IRAEs
#1	F/47Lung adenocarcinoma	durvalumab	Anterior and intermediate uveitis with epiretinal membrane	X	X	X	X	OD 1OS 1	OD 1OS 1	3	14	/
#2	M/59Malignant melanoma	ipilimumab;pembrolizumab	Anterior uveitis (Tyndall 2+), scleritis, and bilateral optic nerve swelling	X	X			OD 0.9OS 0.9	OD 1OS 1	2	65	Myositis
#3	F/36Clear cell renal cell carcinoma	ipilimumab + nivolumab	Persistent anterior uveitis	X		X			OD 1OS 1	1–3	24	Hepatitis
#4	M/77Pleural mesothelioma	ipilimumab + nivolumab	Anterior uveitis (Tyndall 2+)	X	X			OD 1OS 1		2	8	Peripheral neuropathy
#5	M/68Lung adenocarcinoma	ipilimumab + nivolumab	Panuveitis with mutton fat keratic precipitates		X	X			OD 0.8OS 0.8	3	6	Interstitial nephritis
#6	F/44Malignant melanoma	ipilimumab +nivolumab	Anterior uveitis (Tyndall 3+)	X				OD 1OS 1	OD 0.9OS 0.9	3	3	Hypophysitis
#7	M/52Malignant melanoma	ipilimumab +nivolumab	Recurrent anterior uveitis with mutton fat keratic precipitate (Tyndall 1+)	X	X	X		OD 1OS 1	OD 1OS 1	2	2	Vitiligo
#8	F/52Malignant melanoma	ipilimumab +nivolumab	Hypertensive posterior uveitiswith retinal vasculitis	X				OD 0.7OS 1	OD 0.8OS 0.8	3	6	Cochlear neuritis
#9	F/58Malignant melanoma	ipilimumab +nivolumab	VKH-like syndrome: anterior uveitis with multiple white spots on the posterior pole	X				OD 0.7OS 0.4	OD 1OS 1	3	4	Lymphocytic meningitis and vitiligo
#10	M/44Malignant melanoma	ipilimumab + nivolumab	Anterior uveitis with mutton fat keratic precipitates and anterior Tyndall effect 2+	X	X	X		OD 1OS 1	OD 1OS 1	2	3	Vitiligo
#11	M/59Lung adenocarcinoma	nivolumab	Anterior uveitis	X	X	X	X	OD 1OS 0.7	OD 1OS 1	1–3	4	/
#12	M/64Malignant melanoma	nivolumab	Anterior and intermediate uveitis with iris nodules	X		X	X	OD 1OS 0.7	OD 1OS 0.8	3	8	/
#13	F/76Lung adenocarcinoma	nivolumab	Hypertensive anterior and intermediate uveitis with iris nodules	X	X	X			OD 0.4OS 0.8	3	45	/
#14	M/64Malignant melanoma	nivolumab	Unilateral intermediate uveitis with bilateral papillitis and unilateral acute anterior ischemic optic neuropathy		X			OD 1OS 1	OD 1OS 0.3	3	8	Hypertensive meningitis
#15	F/46Malignant melanoma	nivolumab	Acute panuveitis with bilateral choroidal folds and bilateral papillitis	X	X		X	OD 0.3OS 0.8	OD 0.1OS 0.1(cataract)	3	8	/
#16	F/56Clear cell renal cell carcinoma	nivolumab	Recurrent hypertensive panuveitis with multifocal exudative serous detachment and retinal vasculitis		X	X		OD 1OS 1	OD 0.7OS 0.6	3	13	/
#17	F/40Malignant melanoma	nivolumab	Persistent posterior uveitis with peripheral multifocal choroiditis and bilateral optic nerve edema	X				OD 1OS 1	OD 1OS 1	3	13	Pancreatitis
#18	M/45Clear cell renal cell carcinoma	pembrolizumab	Anterior uveitis and scleritis							1-4	34	Hypothyroidism
#19	M/59Squamous cell lung cancer	pembrolizumab	Persistent panuveitis with mutton fat keratic, Tyndall 1+, macular and papillary edema	X	X	X	X	OD 1OS 0.3	OD 0.9OS 0.8	3	8	/
#20	M/61Malignant melanoma	pembrolizumab	Panuveitis with mutton fat keratic precipitates, macular edema and dry eye syndrome	X	X	X			OD 0.7OS 0.4	3	17	/
#21	F/76Malignant uveal melanoma	pembrolizumab	Panuveitis (vitritis grade 3+)		X		X	OD enucleationOS 1	OD enucleationOS 1	3	5	Colitis
#22	M/73Malignant melanoma	pembrolizumab	Persistent posterior uveitis with macular edema	X				OD 0.7OS 0.4	OD 0.6OS 0.6	3	5	Vitiligo

IRAE = immune-related adverse event; B = bilateral; A = acute; G = granulomatous; S = synechia; BCVA = best-corrected visual acuity (decimal scale); CTCAE = common terminology criteria for adverse events; F = female; M = male; OD = right eye; OS = left eye.

Table 4

Detailed description of non-uveitic ocular IRAEs.

	Gender/Age(years)Neoplasia	ICPI	Ocular IRAE	CTCAE Grade	Onset Time (Weeks)	Other IRAEs
#23	F/57Parotid adenocarcinoma	atezolizumab	Keratoconjunctivitis sicca and conjunctival fibrosis	1–2	34	Lichen planus
#24	M/71Urothelial carcinoma	durvalumab	Sjögren’s syndrome with bilateral conjunctivitis sicca and unilateral blepharitis; no autoimmunity; normal accessory salivary gland biopsy	1–2	16	/
#25	M/69Squamous cell lung cancer	nivolumab	Sjögren’s syndrome with unilateral chronic ulcerative keratitis and corneal graft rejection, antinuclear antibodies without specificity	3	78	/
#26	M/62Squamous cell lung cancer	nivolumab	Keratitis	4	49	/
#27	M/70Lung adenocarcinoma	pembrolizumab	Keratoconjunctivitis sicca	1	6	/
#28	M/80Lung adenocarcinoma	pembrolizumab	Bilateral inflammatory orbitopathy with ophthalmoplegia	3–4	6	Myocarditis

Table 5

Management and outcomes of ocular IRAES.

Case	Ocular IRAE Type	ICPI Discontinuation	Local Treatment	Systemic Treatment	Ophthalmic Evolution	Neoplastic Evolution
#1	Uveitis	Yes	Steroid eye drops	/	Complete remission	Worsening
#2	Uveitis	Yes	Steroid eye drops	Oral steroids	Complete remission	Stable
#3	Uveitis	Yes	/	/	Unknown	Unknown
#4	Uveitis	Yes †	Steroid eye drops	/	Complete remission	Stable
#5	Uveitis	Yes	Steroid eye drops	Oral steroids 1 mg/kg/d	Complete remission	Stable
#6	Uveitis	Yes †	Subconjunctival steroids	/	Stable	Stable
#7	Uveitis	Yes	Steroid eye drops and lacrimal substitute	/	Complete remission	Partial remission
#8	Uveitis	U	Steroid eye drops	Oral steroids 1 mg/kg/d	Partial remission	Complete remission
#9	Uveitis	Yes	Steroid eye drops	IV and oral steroids	Complete remission	Complete remission
#10	Uveitis	Yes †	Steroid and atropine eye drops	/	Complete remission	Stable
#11	Uveitis	No	Subconjunctival steroids	Oral steroids 0.5 mg/kg/d	Complete remission	Complete remission
#12	Uveitis	No	Steroid eye drops	/	Partial remission	Unknown
#13	Uveitis	U	Unspecified	/	Unknown	Unknown
#14	Uveitis + optic neuropathy	Yes	/	/	(Worsening then) partial remission	Unknown
#15	Uveitis	Yes	Intravitreal steroids and steroid eye drops	IV steroids 500 mg × 3, then oral 1 mg/kg/dmethotrexate 0.3 mg/kg/winfliximab 5 mg/kg/m;alpha interferon 180 µg/wabatacept 750 mg/m	Stable	Complete remission
#16	Uveitis	No	Intravitreal steroids, steroid eye drops	Oral steroids 1 mg/kg/d	Partial remission	Stable
#17	Uveitis	Yes	/	Oral steroids 0.5 mg/kg/d (for other IRAEs)	Partial remission	Worsening
#18	Uveitis + ocular surface	Yes	Steroid eye drops	Oral steroids 3 mg/kg/d	Partial remission	Stable
#19	Uveitis	Yes	Subconjunctival steroids, steroid eye drops	Oral steroids 1 mg/kg/d	Partial remission	Stable
#20	Uveitis + ocular surface	No	Steroid eye drops	/	Complete remission	Complete remission
#21	Uveitis	Yes	Subconjunctival steroids, steroid eye drops, atropine eye drops	Oral steroids (for other IRAEs)	Complete remission	Partial remission
#22	Uveitis	No	Steroid eye drops, ketorolac tromethamine	(Topical tacrolimus)	Complete remission	Complete remission
#23	Ocular surface	U	Steroid eye drops and scleral lenses	/	Unknown	Unknown
#24	Ocular surface	Yes	Lacrimal substitute	/	Partial remission	Worsening
#25	Ocular surface	Yes	Subconjunctival steroids,topical ciclosporin7 corneal grafts,enucleation	Oral steroids 1 mg/kg/d	Worsening	Worsening
#26	Ocular surface	Yes	Ciclosporin eye drops	Oral steroids 1 mg/kg/d	Partial remission	Stable
#27	Ocular surface	Yes	/	/	Partial remission	Complete remission
#28	Orbitopathy	Yes	/	IV steroids 1 mg/kg/dmethotrexate 15 mg/wIV immunoglobulins	Complete remission	Partial remission

† nivolumab monotherapy; U = Unknown; d = day; w = week; m = month.

Table 6

Management of ICPI-induced uveitis.

	Anterior Uveitis, n (%)	Intermediate Uveitis,n (%)	Posterior Uveitis,n (%)	Panuveitis,n (%)	Total of Uveitis,n (%)
ICPI management
- Permanent discontinuation	5 (45)	2 (50)	1 (33)	5 (71)	13 (52)
- Continuation	2 (18)	1 (25)	1 (33)	2 (28)	6 (24)
- Monotherapy 1	3 (27)	-	-	-	3 (12)
- Unknown status	1 (9)	1 (25)	1 (33)	-	3 (12)
Topical and systemic steroids	3 (27)	-	1 (33)	6 (86)	10 (40)
Topical steroids only	7 (64)	3 (75)	1 (33)	1 (14)	12 (48)
Systemic steroids only	-	-	1 (33)	-	1 (4)
None	1 (9)	1 (25)	-	-	2 (8)

¹ Nivolumab monotherapy instead of ipilimumab/nivolumab combination therapy.

Table 7

Reported cases of ICPI-induced uveitis.

Type of Uveitis	ICPI	n	ICPI Discontinuation	Management (n Cases)	Neoplastic Evolution (n Cases)	Original Articles
All types	All ICPIs	143
Anterior	All ICPIs	62
	atezolizumab	1	N	Local steroids	Progression (1)	[14]
	durvalumab	2	N (2)	Local steroids (2)	Unknown (2)	[27,37]
	ipilimumab	16	N (2)Y (13)Unknown (1)	Local + systemic steroids (6)Systemic steroids (2)Local steroids (8)	Progression (6)Stable (1)Partial response (3)Complete response (1)Unknown (5)	[14,23,38,39,40,41,42,43,44,45,46,47,48,49]
	ipilimumab + nivolumab	15	N (3)Y (9)Unknown (3)	Local + systemic steroids (4)Local steroids (11)	Stable (2)Partial response (4)Unknown (9)	[16,25,26,27,41,50,51,52,53]
	ipilimumab + pembrolizumab	1	M (1)	Local + systemic steroids (1)	Stable (1)	[54]
	nivolumab	19	N (10)Y (7)Unknown (2)	Local + systemic steroids (9)Local steroids (10)	Progression (2)Partial response (8)Unknown (9)	[14,16,25,26,27,37,38,41,55,56,57,58,59,60,61,62]
	pembrolizumab	8	N (2)Y (6)	Local + systemic steroids (3)Local steroids (4)Systemic steroids (1)	Progression (1)Stable (1)Complete response (2)Unknown (4)	[16,22,26,27,63,64,65,66]
Posterior	All ICPIs	28
	atezolizumab	2	Y (2)	Intravitreal steroids (1)Systemic steroids (1)	Unknown (2)	[22,25]
	cemiplimab	1	Y	Local + systemic steroids	Unknown	[17]
	durvalumab	1	N	Systemic steroids	Unknown	[67]
	ipilimumab	5	Y (4)N (1)	Local + systemic steroids (1) Systemic steroids (3)Local steroids (1)	Progression to death (1)Complete response (1) Unknown (3)	[41,68,69,70,71]
	ipilimumab + nivolumab	3	Y (2)M (1)	Systemic steroids (2)Local steroids (1)	Partial response (1)Unknown (2)	[72,73,74]
	ipilimumab + pembrolizumab	1	Y	Local + systemic steroids	Unknown	[75]
	nivolumab	6	Y (4)N (2)	Intra-ocular steroid implant (1)Local steroids (2)Systemic steroids (1)None (2)	Progression to death (2) Complete response (1) Unknown (3)	[14,76,77,78,79,80]
	pembrolizumab	9	Y (7)N (2)	Local steroids (2)Local + systemic steroids (3)Systemic steroids (1)None (3)	Progression (3)Stable (1)Partial response (2)Unknown (3)	[14,50,78,81,82,83,84,85]
Panuveitis	All ICPIs	26
	ipilimumab	2	Y (1)Unknown (1)	Local + systemic steroids (1)Local steroids (1)	Unknown (2)	[41]
	ipilimumab + nivolumab	5	Y (2)N (2)M (2)	Systemic steroids (1)Local steroids (4)	Partial response (2)Unknown (3)	[11,22,25,27,86]
	nivolumab	6	Y (4)N (1)Unknown (1)	Local + systemic steroids (2)Topical steroids (2)Systemic steroids (2)	Stable (1)Partial response (1)Unknown (4)	[16,22,41,87]
	Pembrolizumab	13	Y (9)N (2)Unknown (1)	Local + systemic steroids (6)Systemic steroids (2)Local steroids (4)No treatment	Progression (3)Partial response (2)Unknown (8)	[11,14,25,50,66,88,89,90,91]
VKH-like	All ICPIs	27
	atezolizumab	1	Y	Local + systemic steroids	Unknown	[92]
	ipilimumab	5	Y (3)N (1)Unknown (1)	Local + systemic steroids (2)Systemic steroids (2)No treatment	Stable (1)Partial response (1)Unknown (3)	[24,27,93,94,95]
	ipilimumab + nivolumab	3	Y (2)N (1)	Local and systemic steroidsSystemic steroids (2)	Progression (1)Partial response (1)Unknown (1)	[27,96,97]
	nivolumab	10	Y (5)N (1)Unknown (4)	Local + systemic steroids (6)Systemic steroids (2)Local steroids (2)	Progression (1)Partial response (1)Complete response (3)Unknown (5)	[60,98,99,100,101,102,103,104]
	pembrolizumab	8	Y (3)N (2)Unknown (3)	Local + systemic steroids (3)Systemic steroids (4)Local steroids (1)	Partial response (1)Unknown (7)	[22,27,105,106,107,108,109]

M = anti-PD1 monotherapy instead of anti-PD1/anti-CTLA-4 combination; N = no; Y = yes.

Table 8

VKH and VKH-like syndrome reported after the use of ICPI.

Type (n)	Cancer (n)	ICPI (n)	Original Articles
Complete VKH syndrome (7)	Melanoma (6)Non-small-cell lung cancer (1)	ipilimumab (3)nivolumab (1)pembrolizumab (3)	[22,93,94,95,98,105,106]
Incomplete VKH syndrome with neurological manifestations (5)	Melanoma (2)Non-small-cell lung cancer (3)	atezolizumab (1)nivolumab (2)pembrolizumab (2)	[92,98,99,107,108]
Incomplete VKH syndrome with cutaneous manifestations (6)	Melanoma (6) whom one choroidal melanoma	ipilimumab + nivolumab (2)nivolumab (3)pembrolizumab (1)	[27,96,100,101,102,109]
VKH-like uveitis (9)	Melanoma (5)Renal cell carcinoma (1)Hypopharyngeal and pharyngeal carcinoma (2)Ovarian cancer (1)	ipilimumab (2)ipilimumab + nivolumab (1)nivolumab (4)pembrolizumab (2)	[22,24,27,60,97,103,104]

Supplementary Materials

The following supporting information can be download at https://www.mdpi.com/article/10.3390/jcm11174993/s1, Figure S1: Distribution of uveitis depending on the ICPI; Figure S2: Neoplastic outcome depending on the type ocular IRAEs at the end of follow-up; Figure S3: ICPI indications; Figure S3: Unilateral or bilateral nature of the uveitis, depending on the type of uveitis; Figure S4: Discontinuation of ICPI (a) and treatment (b) depending on the type of uveitis; Table S1: Repartition of uveitis depending on ICPI.

References

1. Vaddepally, R.K.; Kharel, P.; Pandey, R.; Garje, R.; Chandra, A.B. Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence. Cancers; 2020; 12, 738. [DOI: https://dx.doi.org/10.3390/cancers12030738] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32245016]

2. Yi, M. Combination strategies with PD-1/PD-L1 blockade: Current advances and future directions. Mol. Cancer; 2022; 21, 28. [DOI: https://dx.doi.org/10.1186/s12943-021-01489-2] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/35062949]

3. Andrews, L.P.; Cillo, A.R.; Karapetyan, L.; Kirkwood, J.M.; Workman, C.J.; Vignali, D.A. Molecular Pathways and Mechanisms of LAG-3 in Cancer Therapy. Clin. Cancer Res.; 2022; pp. OF1-OF10. [DOI: https://dx.doi.org/10.1158/1078-0432.CCR-21-2390] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/35579997]

4. Wolchok, J.D.; Saenger, Y. The Mechanism of Anti-CTLA-4 Activity and the Negative Regulation of T-Cell Activation. Oncologist; 2008; 13, pp. 2-9. [DOI: https://dx.doi.org/10.1634/theoncologist.13-S4-2]

5. Blank, C.U. The perspective of immunotherapy: New molecules and new mechanisms of action in immune modulation. Curr. Opin. Oncol.; 2014; 26, pp. 204-214. [DOI: https://dx.doi.org/10.1097/CCO.0000000000000054]

6. Postow, M.A.; Sidlow, R.; Hellmann, M.D. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N. Engl. J. Med.; 2018; 378, pp. 158-168. [DOI: https://dx.doi.org/10.1056/NEJMra1703481] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29320654]

7. Lemiale, V. Groupe De Recherche En Reanimation Respiratoire Du Patient D’Onco-Hématologie (Grrr-Oh) Meert, A.-P.; Vincent, F.; Darmon, M.; Bauer, P.R.; Van De Louw, A.; Azoulay, E. Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?. Ann. Intensiv. Care; 2019; 9, 25. [DOI: https://dx.doi.org/10.1186/s13613-019-0487-x]

8. Abdel-Wahab, N.; Alshawa, A.; Suarez-Almazor, M.E. Adverse events in cancer immunotherapy. Advances in Experimental Medicine and Biology; Nadicinge, A.; Hajjar, J. Springer: New York, NY, USA, 2017; Volume 995, pp. 155-174. [DOI: https://dx.doi.org/10.1007/978-3-319-53156-4_8]

9. Cunningham, E.T.; Moorthy, R.S.; Zierhut, M. Immune Checkpoint Inhibitor-Induced Uveitis. Ocul. Immunol. Inflamm.; 2020; 28, pp. 847-849. [DOI: https://dx.doi.org/10.1080/09273948.2020.1801286]

10. Young, L.; Finnigan, S.; Streicher, H.; Chen, H.X.; Murray, J.; Sen, H.N.; Sharon, E. Ocular adverse events in PD-1 and PD-L1 inhibitors. J. Immunother. Cancer; 2021; 9, e002119. [DOI: https://dx.doi.org/10.1136/jitc-2020-002119]

11. Sun, M.M.; Kelly, S.P.; Mylavarapu, B.A.L.; Holland, G.N.; Coleman, A.L.; Yu, F.; Hsu, M.S.; Lum, F.; Gordon, L.K. Ophthalmic Immune-Related Adverse Events after Anti-CTLA-4 or PD-1 Therapy Recorded in the American Academy of Ophthalmology Intelligent Research in Sight Registry. Ophthalmology; 2021; 128, pp. 910-919. [DOI: https://dx.doi.org/10.1016/j.ophtha.2020.11.001]

12. Dalvin, L.A.; Shields, C.L.; Orloff, M.; Sato, T.; Shields, J.A. Checkpoint inhibitor immune therapy: Systemic indications and ophthalmic side effects. Retina; 2018; 38, pp. 1063-1078. [DOI: https://dx.doi.org/10.1097/IAE.0000000000002181] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29689030]

13. Bomze, D.; Meirson, T.; Ali, O.H.; Goldman, A.; Flatz, L.; Habot-Wilner, Z. Ocular Adverse Events Induced by Immune Checkpoint Inhibitors: A Comprehensive Pharmacovigilance Analysis. Ocul. Immunol. Inflamm.; 2022; 30, pp. 191-197. [DOI: https://dx.doi.org/10.1080/09273948.2020.1773867] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32749899]

14. Fortes, B.H.; Liou, H.; Dalvin, L.A. Ophthalmic adverse effects of immune checkpoint inhibitors: The Mayo Clinic experience. Br. J. Ophthalmol.; 2021; 105, pp. 1263-1271. [DOI: https://dx.doi.org/10.1136/bjophthalmol-2020-316970]

15. Antoun, J.; Titah, C.; Cochereau, I. Ocular and orbital side-effects of checkpoint inhibitors: A review article. Curr. Opin. Oncol.; 2016; 28, pp. 288-294. [DOI: https://dx.doi.org/10.1097/CCO.0000000000000296]

16. Bitton, K.; Michot, J.-M.; Barreau, E.; Lambotte, O.; Haigh, O.; Marabelle, A.; Voisin, A.-L.; Mateus, C.; Rémond, A.-L.; Couret, C. et al. Prevalence and Clinical Patterns of Ocular Complications Associated with Anti-PD-1/PD-L1 Anticancer Immunotherapy. Am. J. Ophthalmol.; 2020; 202, pp. 109-117. [DOI: https://dx.doi.org/10.1016/j.ajo.2019.02.012]

17. Dow, E.R.; Yung, M.; Tsui, E. Immune Checkpoint Inhibitor-associated Uveitis: Review of Treatments and Outcomes. Ocul. Immunol. Inflamm.; 2021; 29, pp. 203-211. [DOI: https://dx.doi.org/10.1080/09273948.2020.1781902]

18. Park, R.B.; Jain, S.; Han, H.; Park, J. Ocular surface disease associated with immune checkpoint inhibitor therapy. Ocul. Surf.; 2021; 20, pp. 115-129. [DOI: https://dx.doi.org/10.1016/j.jtos.2021.02.004]

19. Alba-Linero, C.; Alba, E. Ocular side effects of checkpoint inhibitors. Surv. Ophthalmol.; 2021; 66, pp. 951-959. [DOI: https://dx.doi.org/10.1016/j.survophthal.2021.01.001] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/33440195]

20. Wladis, E.J.; Kambam, M.L. Ophthalmic complications of immune checkpoint inhibitors. Orbit; 2021; 41, pp. 28-33. [DOI: https://dx.doi.org/10.1080/01676830.2020.1867192]

21. Liu, X.; Wang, Z.; Zhao, C.; Wang, H.; Guo, X.; Zhou, J.; Duan, L.; Si, X.; Zhang, L.; Li, Y. et al. Clinical diagnosis and treatment recommendations for ocular toxicities of targeted therapy and immune checkpoint inhibitor therapy. Thorac. Cancer; 2020; 11, pp. 810-818. [DOI: https://dx.doi.org/10.1111/1759-7714.13327]

22. Conrady, C.D.; LaRochelle, M.; Pecen, P.; Palestine, A.; Shakoor, A.; Singh, A. Checkpoint inhibitor-induced uveitis: A case series. Graefes Arch. Clin. Exp. Ophthalmol.; 2018; 256, pp. 187-191. [DOI: https://dx.doi.org/10.1007/s00417-017-3835-2] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29080102]

23. Papavasileiou, E.; Prasad, S.; Freitag, S.K.; Sobrin, L.; Lobo, A.-M. Ipilimumab-induced Ocular and Orbital Inflammation—A Case Series and Review of the Literature. Ocul. Immunol. Inflamm.; 2016; 24, pp. 140-146. [DOI: https://dx.doi.org/10.3109/09273948.2014.1001858] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25760920]

24. Fierz, F.C.; Meier, F.; Chaloupka, K.; Böni, C. Intraocular Inflammation Associated with New Therapies for Cutaneous Melanoma—Case Series and Review. Klin. Mon. Augenheilkd; 2016; 233, pp. 540-544. [DOI: https://dx.doi.org/10.1055/s-0042-102668] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27116532]

25. Venkat, A.G.; Arepalli, S.; Sharma, S.; Karthik, N.; Lowder, C.; Ehlers, J.P.; Singh, A.; Goshe, J.; Srivastava, S. Local therapy for cancer therapy-associated uveitis: A case series and review of the literature. Br. J. Ophthalmol.; 2020; 104, pp. 703-711. [DOI: https://dx.doi.org/10.1136/bjophthalmol-2019-314403]

26. Shahzad, O.; Thompson, N.; Clare, G.; Welsh, S.; Damato, E.; Corrie, P. Ocular adverse events associated with immune checkpoint inhibitors: A novel multidisciplinary management algorithm. Ther. Adv. Med Oncol.; 2021; 13, 2989. [DOI: https://dx.doi.org/10.1177/1758835921992989]

27. Noble, C.W.; Gangaputra, S.S.; Thompson, I.A.; Yuan, A.; Apolo, A.B.; Lee, J.-M.; Papaliodis, G.N.; Kodati, S.; Bishop, R.; Magone, M.T. et al. Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies. Ocul. Immunol. Inflamm.; 2020; 28, pp. 854-859. [DOI: https://dx.doi.org/10.1080/09273948.2019.1583347]

28. Fang, W.; Yang, P. Vogt-Koyanagi-Harada Syndrome. Curr. Eye Res.; 2008; 33, pp. 517-523. [DOI: https://dx.doi.org/10.1080/02713680802233968]

29. Thurau, S.; Engelke, H.; McCluskey, P.; Symes, R.J.; Whist, E.; Teuchner, B.; Haas, G.; Allegri, P.; Cimino, L.; Bolletta, E. et al. Uveitis in Tumor Patients Treated with Immunological Checkpoint- and Signal Transduction Pathway-Inhibitors. Ocul. Immunol. Inflamm.; 2021; pp. 1-7. [DOI: https://dx.doi.org/10.1080/09273948.2021.1910850]

30. Touhami, S.; Audo, I.; Terrada, C.; Gaudric, A.; LeHoang, P.; Touitou, V.; Bodaghi, B. Neoplasia and intraocular inflammation: From masquerade syndromes to immunotherapy-induced uveitis. Prog. Retin. Eye Res.; 2019; 72, 100761. [DOI: https://dx.doi.org/10.1016/j.preteyeres.2019.05.002]

31. Jabs, D.A.; Nussenblatt, R.B.; Rosenbaum, J.T. Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop. Am. J. Ophthalmol.; 2005; 140, pp. 509-516. [DOI: https://dx.doi.org/10.1016/j.ajo.2005.03.057]

32. Common Terminology Criteria for Adverse Events (CTCAE) Version 5; US Department of Health and Human Services, National Institutes of Health, National Cancer Institute: Bethesda, MD, USA, 2017.

33. Levinson, R.D.; Brezin, A.; Rothova, A.; Accorinti, M.; Holland, G.N. Research Criteria for the Diagnosis of Birdshot Chorioretinopathy: Results of an International Consensus Conference. Am. J. Ophthalmol.; 2006; 141, pp. 185-187. [DOI: https://dx.doi.org/10.1016/j.ajo.2005.08.025] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16386995]

34. Costabel, U.; Hunninghake, G. on behalf of the Sarcoidosis Statement Committee. ATS/ERS/WASOG statement on sarcoidosis. Eur. Respir. J.; 1999; 14, pp. 735-737. [DOI: https://dx.doi.org/10.1034/j.1399-3003.1999.14d02.x] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10573213]

35. Abad, S.; Meyssonier, V.; Allali, J.; Gouya, H.; Giraudet, A.L.; Monnet, D.; Parc, C.; Tenenbaum, F.; Alberini, J.L.; Grabar, S. et al. Association of peripheral multifocal choroiditis with sarcoidosis: A study of thirty-seven patients. Arthritis Care Res.; 2004; 51, pp. 974-982. [DOI: https://dx.doi.org/10.1002/art.20839] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15593175]

36. Read, R.W.; Holland, G.N.; Rao, N.A.; Tabbara, K.F.; Ohno, S.; Arellanes-Garcia, L.; Pivetti-Pezzi, P.; Tessler, H.H.; Usui, M. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: Report of an international committee on nomenclature. Am. J. Ophthalmol.; 2001; 131, pp. 647-652. [DOI: https://dx.doi.org/10.1016/S0002-9394(01)00925-4]

37. Parikh, R.A.; Chaon, B.C.; Berkenstock, M.K. Ocular Complications of Checkpoint Inhibitors and Immunotherapeutic Agents: A Case Series. Ocul. Immunol. Inflamm.; 2021; 29, pp. 1585-1590. [DOI: https://dx.doi.org/10.1080/09273948.2020.1766082]

38. Deitch-Harel, I.; Raskin, E.; Habot-Wilner, Z.; Friling, R.; Amer, R.; Kramer, M. Uveitis Induced by Biological Agents Used in Cancer Therapy. Ocul. Immunol. Inflamm.; 2021; 29, pp. 1370-1374. [DOI: https://dx.doi.org/10.1080/09273948.2020.1760310]

39. Liao, B.; Shroff, S.; Kamiya-Matsuoka, C.; Tummala, S. Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma. Neuro-Oncology; 2014; 16, pp. 589-593. [DOI: https://dx.doi.org/10.1093/neuonc/nou001]

40. Sanderson, K.; Scotland, R.; Lee, P.; Liu, D.; Groshen, S.; Snively, J.; Sian, S.; Nichol, G.; Davis, T.; Keler, T. et al. Autoimmunity in a Phase I Trial of a Fully Human Anti-Cytotoxic T-Lymphocyte Antigen-4 Monoclonal Antibody with Multiple Melanoma Peptides and Montanide ISA 51 for Patients with Resected Stages III and IV Melanoma. J. Clin. Oncol.; 2005; 23, pp. 741-750. [DOI: https://dx.doi.org/10.1200/JCO.2005.01.128]

41. Sun, M.M.; Levinson, R.D.; Filipowicz, A.; Anesi, S.; Kaplan, H.J.; Wang, W.; Debra, M.D.A.G.; Gangaputra, S.; Swan, R.T.; Sen, H.N. et al. Uveitis in Patients Treated with CTLA-4 and PD-1 Checkpoint Blockade Inhibition. Ocul. Immunol. Inflamm.; 2020; 28, pp. 217-227. [DOI: https://dx.doi.org/10.1080/09273948.2019.1577978]

42. Kiratli, H.; Mocan, M.C.; Irkeç, M. In vivo Confocal Microscopy in Differentiating Ipilimumab-Induced Anterior Uveitis from Metastatic Uveal Melanoma. Case Rep. Ophthalmol.; 2016; 7, pp. 404-409. [DOI: https://dx.doi.org/10.1159/000448730]

43. Zibelman, M.; Olszanski, A.J. Full Spectrum: Efficacy and Toxicity of Immunotherapy in Metastatic Melanoma. J. Natl. Compr. Cancer Netw.; 2014; 12, pp. S1-S5. [DOI: https://dx.doi.org/10.6004/jnccn.2014.0216] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31094496]

44. Robinson, M.R.; Chan, C.-C.; Yang, J.C.; Rubin, B.I.; Gracia, G.J.; Sen, H.N.; Csaky, K.G.; Rosenberg, S.A. Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma: A New Cause of Uveitis. J. Immunother.; 2004; 27, pp. 478-479. [DOI: https://dx.doi.org/10.1097/00002371-200411000-00008]

45. Miserocchi, E.; Cimminiello, C.; Mazzola, M.; Russo, V.; Modorati, G.M. New-onset uveitis during CTLA-4 blockade therapy with ipilimumab in metastatic melanoma patient. Can. J. Ophthalmol.; 2015; 50, pp. e2-e4. [DOI: https://dx.doi.org/10.1016/j.jcjo.2014.10.010] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25677296]

46. Nallapaneni, N.N.; Mourya, R.; Bhatt, V.R.; Malhotra, S.; Ganti, A.K.; Tendulkar, K.K. Ipilimumab-induced hypophysitis and uveitis in a patient with metastatic melanoma and a history of ipilimumab-induced skin rash. J. Natl. Compr. Cancer Netw.; 2014; 12, pp. 1077-1081. [DOI: https://dx.doi.org/10.6004/jnccn.2014.0105]

47. Numata, S.; Okumura, R.; Arima, M.; Kobayashi, T.; Watanabe, S.; Suzuki, K.; Horiguchi, M.; Sugiura, K.; Iwata, Y. Bilateral anterior uveitis and unilateral facial palsy due to ipilimumab for metastatic melanoma in an individual with human leukocyte antigen DR4: A case report. J. Dermatol.; 2018; 45, pp. 113-114. [DOI: https://dx.doi.org/10.1111/1346-8138.13779] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28225147]

48. Yeh, O.L.; Francis, C.E. Ipilimumab-Associated Bilateral Optic Neuropathy. J. Neuro-Ophthalmol.; 2015; 35, pp. 144-147. [DOI: https://dx.doi.org/10.1097/WNO.0000000000000217]

49. Hahn, L.; Pepple, K.L. Bilateral neuroretinitis and anterior uveitis following ipilimumab treatment for metastatic melanoma. J. Ophthalmic Inflamm. Infect.; 2016; 6, 14. [DOI: https://dx.doi.org/10.1186/s12348-016-0082-3]

50. Kim, Y.J.; Lee, J.S.; Lee, J.; Lee, S.C.; Kim, T.-I.; Byeon, S.H.; Lee, C.S. Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. Cancer Immunol. Immunother.; 2020; 69, pp. 2441-2452. [DOI: https://dx.doi.org/10.1007/s00262-020-02635-3]

51. Chan, P.Y.; Hall, P.; Hay, G.; Cohen, V.; Szlosarek, P.W. A major responder to ipilimumab and nivolumab in metastatic uveal melanoma with concomitant autoimmunity. Pigment Cell Melanoma Res.; 2017; 30, pp. 558-562. [DOI: https://dx.doi.org/10.1111/pcmr.12607]

52. Lee, J.C.; Al-Humimat, G.; Kooner, K.S. Acute Bilateral Uveitis, Hypotony, and Cataracts Associated with Ipilimumab and Nivolumab Therapy: Optical Coherence Tomography Angiography Findings. Case Rep. Ophthalmol.; 2020; 11, pp. 606-611. [DOI: https://dx.doi.org/10.1159/000509629]

53. Godse, R.; Mcgettigan, S.; Schuchter, L.M.; Ellebrecht, C.T.; Chu, E.Y. Vogt–Koyanagi–Harada-like syndrome in the setting of combined anti-PD1/anti-CTLA4 therapy. Clin. Exp. Dermatol.; 2021; 46, pp. 1111-1112. [DOI: https://dx.doi.org/10.1111/ced.14640] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/33846999]

54. Hwang, D.-K.; Chang, C.-J.; Chen, S.-J.; Liu, C.J.-L. Bilateral anterior uveitis after immunotherapy for malignant melanoma. Taiwan J. Ophthalmol.; 2018; 8, pp. 173-175. [DOI: https://dx.doi.org/10.4103/tjo.tjo_88_17] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30294532]

55. Richardson, D.R.; Ellis, B.; Mehmi, I.; Leys, M. Bilateral uveitis associated with nivolumab therapy for metastatic melanoma: A case report. Int. J. Ophthalmol.; 2017; 10, pp. 1183-1186. [DOI: https://dx.doi.org/10.18240/ijo.2017.07.28] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28730129]

56. Rémond, A.-L.; Barreau, E.; Le Hoang, P.; Bodaghi, B. Uvéite bilatérale associée à un traitement par nivolumab. J. Fr. Ophtalmol.; 2018; 41, pp. 536-539. [DOI: https://dx.doi.org/10.1016/j.jfo.2017.10.009]

57. Theillac, C.; Straub, M.; Breton, A.-L.; Thomas, L.; Dalle, S. Bilateral uveitis and macular edema induced by Nivolumab: A case report. BMC Ophthalmol.; 2017; 17, 227. [DOI: https://dx.doi.org/10.1186/s12886-017-0611-3]

58. Kanno, H.; Ishida, K.; Yamada, W.; Nishida, T.; Takahashi, N.; Mochizuki, K.; Mizuno, Y.; Matsuyama, K.; Takahashi, T.; Seishima, M. Uveitis induced by programmed cell death protein 1 inhibitor therapy with nivolumab in metastatic melanoma patient. J. Infect. Chemother.; 2017; 23, pp. 774-777. [DOI: https://dx.doi.org/10.1016/j.jiac.2017.04.007]

59. Karlin, J.; Gentzler, R.; Golen, J. Bilateral Anterior Uveitis Associated with Nivolumab Therapy. Ocul. Immunol. Inflamm.; 2018; 26, pp. 283-285. [DOI: https://dx.doi.org/10.1080/09273948.2016.1215473]

60. Kikuchi, R.; Kawagoe, T.; Hotta, K. Vogt–Koyanagi–Harada disease-like uveitis following nivolumab administration treated with steroid pulse therapy: A case report. BMC Ophthalmol.; 2020; 20, 252. [DOI: https://dx.doi.org/10.1186/s12886-020-01519-5]

61. Tugan, B.Y.; Ozkan, B.; Sonmez, O. Recurrent Episodes with Serous Retinal Detachment and Anterior Uveitis in a Patient Using Nivolumab (Anti -PD-1 Antibody) Therapy: A case report and literature review. Semin. Ophthalmol.; 2021; 36, pp. 794-799. [DOI: https://dx.doi.org/10.1080/08820538.2021.1906916]

62. Gonzales, J.A.; Shantha, J.; Acharya, N.R. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. Am. J. Ophthalmol. Case Rep.; 2018; 10, pp. 117-118. [DOI: https://dx.doi.org/10.1016/j.ajoc.2018.02.005]

63. Abu Samra, K.; Valdes-Navarro, M.; Lee, S.; Swan, R.; Foster, C.S.; Anesi, S.D. A Case of Bilateral Uveitis and Papillitis in a Patient Treated with Pembrolizumab. Eur. J. Ophthalmol.; 2016; 26, pp. e46-e48. [DOI: https://dx.doi.org/10.5301/ejo.5000724] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26692064]

64. Basilious, A.; Lloyd, J.C. Posterior subcapsular cataracts and hypotony secondary to severe pembrolizumab induced uveitis: Case report. Can. J. Ophthalmol.; 2016; 51, pp. e4-e6. [DOI: https://dx.doi.org/10.1016/j.jcjo.2015.09.008] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26874174]

65. Manusow, J.S.; Khoja, L.; Pesin, N.; Joshua, A.M.; Mandelcorn, E.D. Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma. J. Immunother. Cancer; 2014; 2, 41. [DOI: https://dx.doi.org/10.1186/s40425-014-0041-1] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25516805]

66. Diem, S.; Keller, F.; Rüesch, R.; Maillard, S.A.; Speiser, D.E.; Dummer, R.; Siano, M.; Urner-Bloch, U.; Goldinger, S.M.; Flatz, L. Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?. J. Immunother.; 2016; 39, pp. 379-382. [DOI: https://dx.doi.org/10.1097/CJI.0000000000000143] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27662340]

67. Andrade, A.R.; Moll-Udina, A.; Martin, R.; Cilveti, E.; Subirà, O.; Disfetano, L.; García-Arumí, J. Retinal Vasculitis Secondary to Durvalumab. Case Rep. Ophthalmol.; 2020; 11, pp. 161-166. [DOI: https://dx.doi.org/10.1159/000507609]

68. Tan, A.X.; Ang, A.; Campbell, W.; Fabinyi, D.C. Bilateral ipilimumab-induced posterior uveitis following treatment for metastatic choroidal melanoma. Clin. Exp. Ophthalmol.; 2018; 46, pp. 819-821. [DOI: https://dx.doi.org/10.1111/ceo.13197]

69. Modjtahedi, B.S.; Maibach, H.; Park, S. Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma. Cutan. Ocul. Toxicol.; 2013; 32, pp. 341-343. [DOI: https://dx.doi.org/10.3109/15569527.2013.781618]

70. Mantopoulos, D.; Kendra, K.L.; Letson, A.D.; Cebulla, C.M. Bilateral Choroidopathy and Serous Retinal Detachments During Ipilimumab Treatment for Cutaneous Melanoma. JAMA Ophthalmol.; 2015; 133, pp. 965-967. [DOI: https://dx.doi.org/10.1001/jamaophthalmol.2015.1128]

71. Miyakubo, T.; Mukai, R.; Nakamura, K.; Matsumoto, H.; Akiyama, H. A Case of Ipilimumab-Induced Unusual Serous Retinal Detachment in Bilateral Eyes. Int. Med. Case Rep. J.; 2019; 12, pp. 355-361. [DOI: https://dx.doi.org/10.2147/IMCRJ.S225173]

72. Tsui, E.; Madu, A.; Belinsky, I.; Yannuzzi, L.A.; Freund, K.B.; Modi, Y.S. Combination Ipilimumab and Nivolumab for Metastatic Melanoma Associated with Ciliochoroidal Effusion and Exudative Retinal Detachment. JAMA Ophthalmol.; 2017; 135, pp. 1455-1457. [DOI: https://dx.doi.org/10.1001/jamaophthalmol.2017.4872]

73. Elwood, K.F.; Pulido, J.S.; Ghafoori, S.D.; Harper, C.A.; Wong, R.W. Choroidal neovascularization and chorioretinal atrophy in a patient with melanoma-associated retinopathy after ipilimumab/nivolumab combination therapy. Retin. Cases Brief Rep.; 2021; 15, pp. 514-518. [DOI: https://dx.doi.org/10.1097/ICB.0000000000000882] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31246886]

74. Rapisuwon, S.; Izar, B.; Batenchuk, C.; Avila, A.; Mei, S.; Sorger, P.; Parks, J.M.; Cooper, C.; Wagner, D.; Zeck, J.C. et al. Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors. J. Immunother. Cancer; 2019; 7, 61. [DOI: https://dx.doi.org/10.1186/s40425-019-0533-0] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30832716]

75. O’Bryhim, B.E.; Sychev, Y.; Rao, P.K. Bilateral choroidal detachments secondary to ipilimumab and pembrolizumab use. Retin. Cases Brief Rep.; 2021; 15, pp. 230-233. [DOI: https://dx.doi.org/10.1097/ICB.0000000000000785] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30044269]

76. De Velasco, G.; Bermas, B.; Choueiri, T.K. Autoimmune Arthropathy and Uveitis as Complications of Programmed Death 1 Inhibitor Treatment. Arthritis Rheumatol.; 2016; 68, pp. 556-557. [DOI: https://dx.doi.org/10.1002/art.39406] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26314277]

77. Ung, C.; Gragoudas, E. Checkpoint inhibitor-induced sarcoid choroidal granulomas. Am. J. Ophthalmol. Case Rep.; 2020; 18, 100652. [DOI: https://dx.doi.org/10.1016/j.ajoc.2020.100652]

78. Thomas, M.; Armenti, S.T.; Ayres, M.B.; Demirci, H. Uveal Effusion After Immune Checkpoint Inhibitor Therapy. JAMA Ophthalmol.; 2018; 136, 553. [DOI: https://dx.doi.org/10.1001/jamaophthalmol.2018.0920]

79. Miyamoto, R.; Nakashizuka, H.; Tanaka, K.; Wakatsuki, Y.; Onoe, H.; Mori, R.; Kawamura, A. Bilateral multiple serous retinal detachments after treatment with nivolumab: A case report. BMC Ophthalmol.; 2020; 20, 221. [DOI: https://dx.doi.org/10.1186/s12886-020-01495-w]

80. Reddy, M.; Chen, J.J.; Kalevar, A.; Terribilini, R.; Agarwal, A. Immune retinopathy associated with nivolumab administration for metastatic non–small cell lung cancer. Retin. Cases Brief Rep.; 2020; 14, pp. 120-126. [DOI: https://dx.doi.org/10.1097/ICB.0000000000000675]

81. Aaberg, M.T.; Aaberg, T.M. Pembrolizumab administration associated with posterior uveitis. Retin. Cases Brief Rep.; 2017; 11, pp. 348-351. [DOI: https://dx.doi.org/10.1097/icb.0000000000000368]

82. Telfah, M.; Whittaker, T.J.; Doolittle, G.C. Vision loss with pembrolizumab treatment: A report of two cases. J. Oncol. Pharm. Pract.; 2019; 25, pp. 1540-1546. [DOI: https://dx.doi.org/10.1177/1078155219841683]

83. Peng, L.; Mao, Q.-Q.; Jiang, B.; Zhang, J.; Zhao, Y.-L.; Teng, X.-D.; Yang, J.-S.; Xia, Y.; Chen, S.-Q.; Stebbing, J. et al. Bilateral Posterior Uveitis and Retinal Detachment During Immunotherapy: A Case Report and Literature Review. Front. Oncol.; 2020; 10, 549168. [DOI: https://dx.doi.org/10.3389/fonc.2020.549168] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/33240807]

84. Acaba-Berrocal, L.A.; Lucio-Alvarez, J.A.; Mashayekhi, A.; Ho, A.C.; Dunn, J.P.; Shields, C.L. Birdshot-like Chorioretinopathy Associated with Pembrolizumab Treatment. JAMA Ophthalmol.; 2018; 136, pp. 1205-1207. [DOI: https://dx.doi.org/10.1001/jamaophthalmol.2018.1851] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30054605]

85. Lambert, I.; Fasolino, G.; Awada, G.; Kuijpers, R.; Tusscher, M.T.; Neyns, B. Acute exudative polymorphous vitelliform maculopathy during pembrolizumab treatment for metastatic melanoma: A case report. BMC Ophthalmol.; 2021; 21, 250. [DOI: https://dx.doi.org/10.1186/s12886-021-02011-4] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/34090381]

86. Hefler, J.L.; Bailey, L.M.; El Rahi, C.; Schefler, A.C.; Bernicker, E.H. Panuveitis in patient on ipilimumab/nivolumab combination for small-cell lung cancer treated with an intravitreal dexamethasone implant. J. Oncol. Pharm. Pract.; 2021; 27, pp. 1261-1264. [DOI: https://dx.doi.org/10.1177/1078155220969792] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/33108990]

87. Dermarkarian, C.R.; Patel, N.A.; Villegas, V.M.; Harbour, J.W. Bilateral uveitis associated with nivolumab therapy for metastatic non-small cell lung cancer. Am. J. Ophthalmol. Case Rep.; 2020; 18, 100691. [DOI: https://dx.doi.org/10.1016/j.ajoc.2020.100691]

88. Hanna, K.S. A Rare Case of Pembrolizumab-Induced Uveitis in a Patient with Metastatic Melanoma. Pharmacother. J. Hum. Pharmacol. Drug Ther.; 2016; 36, pp. e183-e188. [DOI: https://dx.doi.org/10.1002/phar.1839]

89. Lise, Q.-K.; Audrey, A.-G. Multifocal choroiditis as the first sign of systemic sarcoidosis associated with pembrolizumab. Am. J. Ophthalmol. Case Rep.; 2017; 5, pp. 92-93. [DOI: https://dx.doi.org/10.1016/j.ajoc.2016.12.014]

90. Reid, G.; Lorigan, P.; Heimann, H.; Hovan, M. Management of Chronic Hypotony Following Bilateral Uveitis in a Patient Treated with Pembrolizumab for Cutaneous Metastatic Melanoma. Ocul. Immunol. Inflamm.; 2019; 27, pp. 1012-1015. [DOI: https://dx.doi.org/10.1080/09273948.2018.1459733]

91. Taylor, S.C.; Hrisomalos, F.; Linette, G.P.; Rao, P.K. A case of recurrent bilateral uveitis independently associated with dabrafenib and pembrolizumab therapy. Am. J. Ophthalmol. Case Rep.; 2016; 2, pp. 23-25. [DOI: https://dx.doi.org/10.1016/j.ajoc.2016.04.004]

92. Suwa, S.; Tomita, R.; Kataoka, K.; Ueno, S. Development of Vogt–Koyanagi–Harada Disease-like Uveitis during Treatment by Anti-programmed Death Ligand-1 Antibody for Non-small Cell Lung Cancer: A Case Report. Ocul. Immunol. Inflamm.; 2021; pp. 1-5. [DOI: https://dx.doi.org/10.1080/09273948.2021.1884889]

93. Witmer, M.T. Treatment of Ipilimumab-Induced Vogt-Koyanagi-Harada Syndrome with Oral Dexamethasone. Ophthalmic Surg. Lasers Imaging Retin.; 2017; 48, pp. 928-931. [DOI: https://dx.doi.org/10.3928/23258160-20171030-09] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29121363]

94. Monferrer-Adsuara, C.; Hernández-Bel, L.; Hernández-Garfella, M.L.; Remolí-Sargues, L.; Ortiz-Salvador, M.; Castro-Navarro, V.; Cervera-Taulet, E. Case Report: Ipilimumab-induced Multisystem Autoimmune-like Toxicities Suggestive of Vogt-Koyanagi-Harada–like Syndrome. Optom. Vis. Sci.; 2021; 98, pp. 1309-1316. [DOI: https://dx.doi.org/10.1097/OPX.0000000000001798] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/34510146]

95. Crosson, J.N.; Laird, P.W.; Debiec, M.; Bergstrom, C.S.; Lawson, D.H.; Yeh, S. Vogt-Koyanagi-Harada-like Syndrome After CTLA-4 Inhibition with Ipilimumab for Metastatic Melanoma. J. Immunother.; 2015; 38, pp. 80-84. [DOI: https://dx.doi.org/10.1097/CJI.0000000000000066]

96. Wong, R.K.; Lee, J.K.; Huang, J.J. Bilateral drug (ipilimumab)-induced vitritis, choroiditis, and serous retinal detachments suggestive of vogt–koyanagi–harada syndrome. Retin. Cases Brief Rep.; 2012; 6, pp. 423-426. [DOI: https://dx.doi.org/10.1097/ICB.0b013e31824f7130] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25389947]

97. Minami, K.; Egawa, M.; Kajita, K.; Murao, F.; Mitamura, Y. A Case of Vogt-Koyanagi-Harada Disease-Like Uveitis Induced by Nivolumab and Ipilimumab Combination Therapy. Case Rep. Ophthalmol.; 2021; 12, pp. 952-960. [DOI: https://dx.doi.org/10.1159/000520416] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/35082654]

98. Fujimura, T.; Kambayashi, Y.; Tanita, K.; Sato, Y.; Hidaka, T.; Otsuka, A.; Tanaka, H.; Furudate, S.; Hashimoto, A.; Aiba, S. HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy. J. Dermatol.; 2018; 45, pp. 735-737. [DOI: https://dx.doi.org/10.1111/1346-8138.14273]

99. Ushio, R.; Yamamoto, M.; Miyasaka, A.; Muraoka, T.; Kanaoka, H.; Tamura, H.; Kaneko, A.; Izawa, A.; Hirama, N.; Teranishi, S. et al. Nivolumab-induced Vogt-Koyanagi-Harada-like Syndrome and Adrenocortical Insufficiency with Long-term Survival in a Patient with Non-small-cell Lung Cancer. Intern. Med.; 2021; 60, pp. 3593-3598. [DOI: https://dx.doi.org/10.2169/internalmedicine.6410-20]

100. Obata, S.; Saishin, Y.; Teramura, K.; Ohji, M. Vogt-Koyanagi-Harada Disease-Like Uveitis during Nivolumab (Anti-PD-1 Antibody) Treatment for Metastatic Cutaneous Malignant Melanoma. Case Rep. Ophthalmol.; 2019; 10, pp. 67-74. [DOI: https://dx.doi.org/10.1159/000496682]

101. Matsuo, T.; Yamasaki, O. Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. Clin. Case Rep.; 2017; 5, pp. 694-700. [DOI: https://dx.doi.org/10.1002/ccr3.911]

102. Arai, T.; Harada, K.; Usui, Y.; Irisawa, R.; Tsuboi, R. Case of acute anterior uveitis and Vogt-Koyanagi-Harada syndrome-like eruptions induced by nivolumab in a melanoma patient. J. Dermatol.; 2017; 44, pp. 975-976. [DOI: https://dx.doi.org/10.1111/1346-8138.13612]

103. Wang, W.; Lam, W.-C.; Chen, L. Recurrent grade 4 panuveitis with serous retinal detachment related to nivolumab treatment in a patient with metastatic renal cell carcinoma. Cancer Immunol. Immunother.; 2019; 68, pp. 85-95. [DOI: https://dx.doi.org/10.1007/s00262-018-2260-7]

104. Hwang, G.E.; Lee, J.W.; Jeon, S.; Cho, I.H.; Kim, H.D. Vogt-Koyanagi-Harada syndrome-like uveitis after nivolumab administration as a treatment for ovarian cancer. Doc. Ophthalmol.; 2022; 144, pp. 153-162. [DOI: https://dx.doi.org/10.1007/s10633-021-09862-8]

105. Bricout, M.; Petre, A.; Amini-Adle, M.; Bezza, W.; Seve, P.; Kodjikian, L.; Dalle, S.; Thomas, L. Vogt-Koyanagi-Harada–like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma. J. Immunother.; 2017; 40, pp. 77-82. [DOI: https://dx.doi.org/10.1097/CJI.0000000000000154]

106. Kurono, Y.; Takeda, T.; Kunimatsu, Y.; Tani, N.; Hashimoto, I.; Hirose, K. Vogt–Koyanagi–Harada disease during chemoimmunotherapy for non-small cell lung cancer. Respirol. Case Rep.; 2020; 8, e00545. [DOI: https://dx.doi.org/10.1002/rcr2.545]

107. Tamura, T.; Akimoto, E.; Matsumoto, C.; Mori, S.; Nishi, T.; Kudo, K.; Kuyama, S. Vogt-Koyanagi-Harada Syndrome Induced by Pembrolizumab in a Patient with Non–Small Cell Lung Cancer. J. Thorac. Oncol.; 2018; 13, pp. 1606-1607. [DOI: https://dx.doi.org/10.1016/j.jtho.2018.04.026]

108. Enomoto, H.; Kato, K.; Sugawara, A.; Itabashi, M.; Kondo, M. Case with metastatic cutaneous malignant melanoma that developed Vogt–Koyanagi–Harada-like uveitis following pembrolizumab treatment. Doc. Ophthalmol.; 2021; 142, pp. 353-360. [DOI: https://dx.doi.org/10.1007/s10633-020-09800-0]

109. Yoshida, S.; Shiraishi, K.; Mito, T.; Sayama, K. Vogt–Koyanagi–Harada-like syndrome induced by immune checkpoint inhibitors in a patient with melanoma. Clin. Exp. Dermatol.; 2020; 45, pp. 908-911. [DOI: https://dx.doi.org/10.1111/ced.14282]

110. Bellenghi, M.; Puglisi, R.; Pontecorvi, G.; De De Feo, A.; Carè, A.; Mattia, G. Sex and Gender Disparities in Melanoma. Cancers; 2020; 12, 1819. [DOI: https://dx.doi.org/10.3390/cancers12071819]

111. Lu, T.; Yang, X.; Huang, Y.; Zhao, M.; Li, M.; Ma, K.; Yin, J.; Zhan, C.; Wang, Q. Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades. Cancer Manag. Res.; 2019; 11, pp. 943-953. [DOI: https://dx.doi.org/10.2147/CMAR.S187317]

112. Arnaud-Coffin, P.; Maillet, D.; Gan, H.K.; Stelmes, J.-J.; You, B.; Dalle, S.; Péron, J. A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors. Int. J. Cancer; 2019; 145, pp. 639-648. [DOI: https://dx.doi.org/10.1002/ijc.32132]

113. Duvoisin, R.M.; Ren, G.; Haley, T.L.; Taylor, M.H.; Morgans, C.W. TRPM1 Autoantibodies in Melanoma Patients without Self-Reported Visual Symptoms. Investig. Opthalmol. Vis. Sci.; 2019; 60, pp. 2330-2335. [DOI: https://dx.doi.org/10.1167/iovs.19-26775]

114. Sheldon, C.A.; Kharlip, J.; Tamhankar, M.A. Inflammatory Orbitopathy Associated with Ipilimumab. Ophthalmic Plast. Reconstr. Surg.; 2017; 33, pp. S155-S158. [DOI: https://dx.doi.org/10.1097/IOP.0000000000000509] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26068559]

115. Borodic, G.; Hinkle, D.M.; Cia, Y. Drug-Induced Graves Disease from CTLA-4 Receptor Suppression. Ophthalmic Plast. Reconstr. Surg.; 2011; 27, pp. e87-e88. [DOI: https://dx.doi.org/10.1097/IOP.0b013e3181ef72a1] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21242854]

116. Min, L.; Vaidya, A.; Becker, C. Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy. Eur. J. Endocrinol.; 2011; 164, pp. 303-307. [DOI: https://dx.doi.org/10.1530/EJE-10-0833]

117. McElnea, E.; Ní Mhéalóid, Á.; Moran, S.; Kelly, R.; Fulcher, T. Thyroid-Like Ophthalmopathy in a Euthyroid Patient Receiving Ipilimumab. Orbit; 2014; 33, pp. 424-427. [DOI: https://dx.doi.org/10.3109/01676830.2014.949792] [PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25207976]

118. Henderson, A.D.; Thomas, D.A. A Case Report of Orbital Inflammatory Syndrome Secondary to Ipilimumab. Ophthalmic Plast. Reconstr. Surg.; 2015; 31, pp. e68-e70. [DOI: https://dx.doi.org/10.1097/IOP.0000000000000081]

119. Lecouflet, M.; Verschoore, M.; Giard, C.; Gohier, P.; Le Corre, Y.; Milea, D.; Martin, L. Myosite orbitaire associée à un traitement par ipilimumab. Annales de Dermatologie et de Vénéréologie; Elsevier: Amsterdam, The Netherlands, 2013; Volume 140, pp. 448-451. [DOI: https://dx.doi.org/10.1016/j.annder.2013.02.029]

120. Losonczy, G.; Gijs, M.; Nuijts, R.M. Nivolumab-Induced Ulcerative Keratitis—A Case Report. Cornea; 2021; 40, pp. 656-658. [DOI: https://dx.doi.org/10.1097/ICO.0000000000002460]

121. Bosch-Voskens, C.; Goldinger, S.M.; Loquai, C.; Robert, C.; Kaehler, K.C.; Berking, C.; Bergmann, T.; Bockmeyer, C.L.; Eigentler, T.; Fluck, M. et al. The Price of Tumor Control: An Analysis of Rare Side Effects of Anti-CTLA-4 Therapy in Metastatic Melanoma from the Ipilimumab Network. PLoS ONE; 2013; 8, e53745. [DOI: https://dx.doi.org/10.1371/journal.pone.0053745]

122. Nguyen, A.T.; Elia, M.; Materin, M.A.; Sznol, M.; Chow, J. Cyclosporine for Dry Eye Associated with Nivolumab: A case progressing to corneal perforation. Cornea; 2016; 35, pp. 399-401. [DOI: https://dx.doi.org/10.1097/ICO.0000000000000724]

123. Parker, J.S.; Feagin, W.; Wang, C.; Heersink, M.; Parker, J.S. Corneal ulceration associated with Nivolumab use. Am. J. Ophthalmol. Case Rep.; 2019; 14, pp. 26-27. [DOI: https://dx.doi.org/10.1016/j.ajoc.2019.01.013]

124. Michot, J.; Bigenwald, C.; Champiat, S.; Collins, M.; Carbonnel, F.; Postel-Vinay, S.; Berdelou, A.; Varga, A.; Bahleda, R.; Hollebecque, A. et al. Immune-related adverse events with immune checkpoint blockade: A comprehensive review. Eur. J. Cancer; 2016; 54, pp. 139-148. [DOI: https://dx.doi.org/10.1016/j.ejca.2015.11.016]

125. Topalian, S.L.; Hodi, F.S.; Brahmer, J.R.; Gettinger, S.N.; Smith, D.C.; McDermott, D.F.; Powderly, J.D.; Carvajal, R.D.; Sosman, J.A.; Atkins, M.B. et al. Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer. N. Engl. J. Med.; 2012; 366, pp. 2443-2454. [DOI: https://dx.doi.org/10.1056/NEJMoa1200690]

126. Brahmer, J.R.; Tykodi, S.S.; Chow, L.Q.M.; Hwu, W.-J.; Topalian, S.L.; Hwu, P.; Drake, C.G.; Camacho, L.H.; Kauh, J.; Odunsi, K. et al. Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer. N. Engl. J. Med.; 2012; 366, pp. 2455-2465. [DOI: https://dx.doi.org/10.1056/NEJMoa1200694]

127. Xu, C.; Chen, Y.; Du, X.-J.; Liu, J.-Q.; Huang, C.-L.; Chen, L.; Zhou, G.-Q.; Li, W.-F.; Mao, Y.-P.; Hsu, C. et al. Comparative safety of immune checkpoint inhibitors in cancer: Systematic review and network meta-analysis. BMJ; 2018; 363, k4226. [DOI: https://dx.doi.org/10.1136/bmj.k4226]

128. Hou, Y.-L.; Wang, D.-Y.; Hu, J.-X.; Tian, R.-Y.; Wang, W.; Su, Q.; Li, H.; Wang, Y.-L. Risk of Ophthalmic Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis. Ocul. Immunol. Inflamm.; 2021; pp. 1-11. [DOI: https://dx.doi.org/10.1080/09273948.2021.1890133]

129. Norose, K.; Yano, A. Melanoma specific Th1 cytotoxic T lymphocyte lines in Vogt-Koyanagi-Harada disease. Br. J. Ophthalmol.; 1996; 80, pp. 1002-1008. [DOI: https://dx.doi.org/10.1136/bjo.80.11.1002]

130. Lavezzo, M.M.; Sakata, V.M.; Morita, C.; Rodriguez, E.E.C.; Abdallah, S.F.; Da Silva, F.T.G.; Hirata, C.E.; Yamamoto, J.H. Vogt-Koyanagi-Harada disease: Review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet. J. Rare Dis.; 2016; 11, pp. 1-21. [DOI: https://dx.doi.org/10.1186/s13023-016-0412-4]

131. Shi, T.; Lv, W.; Zhang, L.; Chen, J.; Chen, H. Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis. Sci. Rep.; 2015; 4, 6887. [DOI: https://dx.doi.org/10.1038/srep06887]

132. Zhou, R.; Caspi, R.R. Ocular immune privilege. F1000 Biol. Rep.; 2010; 2, pp. 1-3. [DOI: https://dx.doi.org/10.3410/B2-3]

133. Gkiozos, I.; Kopitopoulou, A.; Kalkanis, A.; Vamvakaris, I.N.; Judson, M.A.; Syrigos, K.N. Sarcoidosis-Like Reactions Induced by Checkpoint Inhibitors. J. Thorac. Oncol.; 2018; 13, pp. 1076-1082. [DOI: https://dx.doi.org/10.1016/j.jtho.2018.04.031]

134. Chanson, N.; Ramos-Casals, M.; Pundole, X.; Suijkerbuijk, K.; Silva, M.J.D.B.E.; Lidar, M.; Benesova, K.; Leipe, J.; Acar-Denizli, N.; Pradère, P. et al. Immune checkpoint inhibitor–associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation. Eur. J. Cancer; 2021; 158, pp. 208-216. [DOI: https://dx.doi.org/10.1016/j.ejca.2021.05.041]

135. Vanhonsebrouck, E.; Van De Walle, M.; Lybaert, W.; Kruse, V.; Roels, D. Bilateral Corneal Graft Rejection Associated with Pembrolizumab Treatment. Cornea; 2020; 39, pp. 1436-1438. [DOI: https://dx.doi.org/10.1097/ICO.0000000000002372]

136. Warner, B.M.; Baer, A.N.; Lipson, E.J.; Allen, C.; Hinrichs, C.; Rajan, A.; Pelayo, E.; Beach, M.; Gulley, J.L.; Madan, R.A. et al. Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy. Oncologist; 2019; 24, pp. 1259-1269. [DOI: https://dx.doi.org/10.1634/theoncologist.2018-0823]

137. Yu, C.W.; Yau, M.; Mezey, N.; Joarder, I.; Micieli, A.J. Neuro-ophthalmic Complications of Immune Checkpoint Inhibitors: A Systematic Review. Eye Brain; 2020; 12, pp. 139-167. [DOI: https://dx.doi.org/10.2147/EB.S277760]

138. Mukharesh, L.; Chwalisz, B.K. Neuro-ophthalmic Complications of Immune-Checkpoint Inhibitors. Semin. Ophthalmol.; 2021; 36, pp. 241-249. [DOI: https://dx.doi.org/10.1080/08820538.2021.1890796]