Abstract

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment.

Details

Title
Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
Author
Petrosyan, Varduhi 1   VIAFID ORCID Logo  ; Dobrolecki, Lacey E. 2   VIAFID ORCID Logo  ; LaPlante, Emily L. 1   VIAFID ORCID Logo  ; Srinivasan, Ramakrishnan Rajaram 2   VIAFID ORCID Logo  ; Bailey, Matthew H. 3 ; Welm, Alana L. 4   VIAFID ORCID Logo  ; Welm, Bryan E. 5   VIAFID ORCID Logo  ; Lewis, Michael T. 6 ; Milosavljevic, Aleksandar 1   VIAFID ORCID Logo 

1  Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X) 
2  Baylor College of Medicine, Lester and Sue Smith Breast Center, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X) 
3  University of Utah, Eccles Institute of Human Genetics, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096); University of Utah, Huntsman Cancer Institute, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096) 
4  University of Utah, Huntsman Cancer Institute, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096); University of Utah, Department of Oncological Sciences, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096) 
5  University of Utah, Huntsman Cancer Institute, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096); University of Utah, Department of Surgery, Salt Lake City, USA (GRID:grid.223827.e) (ISNI:0000 0001 2193 0096) 
6  Baylor College of Medicine, Lester and Sue Smith Breast Center, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X); Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X); Baylor College of Medicine, Departments of Molecular and Cellular Biology and Radiology, Houston, USA (GRID:grid.39382.33) (ISNI:0000 0001 2160 926X) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
23744677
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41523-022-00476-0
ProQuest document ID
2712352861
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.