Abstract

Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.

Exercise modulates brown adipose tissue (BAT) metabolism in murine models. Here the authors report that there is no evidence that 24 weeks of supervised exercise training modulates BAT volume or function in young sedentary adults in the ACTIBATE randomized controlled trial.

Details

Title
No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial
Author
Martinez-Tellez, Borja 1   VIAFID ORCID Logo  ; Sanchez-Delgado, Guillermo 2 ; Acosta, Francisco M. 3 ; Alcantara, Juan M. A. 4 ; Amaro-Gahete, Francisco J. 5 ; Martinez-Avila, Wendy D. 4 ; Merchan-Ramirez, Elisa 4 ; Muñoz-Hernandez, Victoria 4 ; Osuna-Prieto, Francisco J. 6 ; Jurado-Fasoli, Lucas 4 ; Xu, Huiwen 7 ; Ortiz-Alvarez, Lourdes 7 ; Arias-Tellez, María J. 8   VIAFID ORCID Logo  ; Mendez-Gutierrez, Andrea 9 ; Labayen, Idoia 10   VIAFID ORCID Logo  ; Ortega, Francisco B. 11   VIAFID ORCID Logo  ; Schönke, Milena 12 ; Rensen, Patrick C. N. 12   VIAFID ORCID Logo  ; Aguilera, Concepción M. 13   VIAFID ORCID Logo  ; Llamas-Elvira, José M. 14   VIAFID ORCID Logo  ; Gil, Ángel 13   VIAFID ORCID Logo  ; Ruiz, Jonatan R. 15   VIAFID ORCID Logo 

1  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Leiden University Medical Center, Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978); University of Almería, Department of Education, Faculty of Education Sciences and SPORT Research Group (CTS-1024), CERNEP Research Center, Almería, Spain (GRID:grid.28020.38) (ISNI:0000000101969356) 
2  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Pennington Biomedical Research Center, Baton Rouge, USA (GRID:grid.250514.7) (ISNI:0000 0001 2159 6024) 
3  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Turku, Turku PET Centre, Turku, Finland (GRID:grid.1374.1) (ISNI:0000 0001 2097 1371); Turku University Hospital, Turku PET Centre, Turku, Finland (GRID:grid.410552.7) (ISNI:0000 0004 0628 215X); University of Turku, InFLAMES Research Flagship Center, Turku, Finland (GRID:grid.1374.1) (ISNI:0000 0001 2097 1371) 
4  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994) 
5  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); School of Medicine, University of Granada, EFFECTS-262 Research Group, Department of Physiology, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994) 
6  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Granada, Department of Analytical Chemistry, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Research and Development of Functional Food Center (CIDAF), Granada, Spain (GRID:grid.4489.1) 
7  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Granada, Department of Biochemistry and Molecular Biology II, “José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994) 
8  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Chile, Independence, Department of Nutrition, Faculty of Medicine, Santiago, Chile (GRID:grid.443909.3) (ISNI:0000 0004 0385 4466) 
9  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Granada, Department of Biochemistry and Molecular Biology II, “José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Instituto de Investigación Biosanitaria, ibs.Granada, Granada, Spain (GRID:grid.507088.2); CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain (GRID:grid.484042.e) (ISNI:0000 0004 5930 4615) 
10  Public University of Navarra, Campus de Arrosadía, Institute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Pamplona, Spain (GRID:grid.410476.0) (ISNI:0000 0001 2174 6440) 
11  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); University of Jyväskylä, Faculty of Sport and Health Sciences, Jyväskylä, Finland (GRID:grid.9681.6) (ISNI:0000 0001 1013 7965) 
12  Leiden University Medical Center, Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands (GRID:grid.10419.3d) (ISNI:0000000089452978) 
13  University of Granada, Department of Biochemistry and Molecular Biology II, “José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Instituto de Investigación Biosanitaria, ibs.Granada, Granada, Spain (GRID:grid.507088.2); CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain (GRID:grid.484042.e) (ISNI:0000 0004 5930 4615) 
14  Instituto de Investigación Biosanitaria, ibs.Granada, Granada, Spain (GRID:grid.507088.2); Virgen de las Nieves University Hospital, Nuclear Medicine Service, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Biohealth Research Institute in Granada, Nuclear Medicine Department, Granada, Spain (GRID:grid.411380.f) 
15  University of Granada, PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994); Instituto de Investigación Biosanitaria, ibs.Granada, Granada, Spain (GRID:grid.507088.2) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-022-32502-x
ProQuest document ID
2713128936
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.