Abstract

Background

Mechanisms by which AKI leads to CKD progression remain unclear. Several urine biomarkers have been identified as independent predictors of progressive CKD. It is unknown whether AKI may result in long-term changes in these urine biomarkers, which may mediate the effect of AKI on CKD progression.

Methods

We selected 198 episodes of hospitalized AKI (defined as peak/nadir inpatient serum creatinine values ≥ 1.5) among adult participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. We matched the best non-AKI hospitalization (unique patients) for each AKI hospitalization using pre-hospitalization characteristics including eGFR and urine protein/creatinine ratio. Biomarkers were measured in banked urine samples collected at annual CRIC study visits.

Results

Urine biomarker measurements occurred a median of 7 months before and 5 months after hospitalization. There were no significant differences in the change in urine biomarker-to-creatinine ratio between the AKI and non-AKI groups: KIM-1/Cr + 9% vs + 7%, MCP-1/Cr + 4% vs + 1%, YKL-40/Cr + 7% vs -20%, EGF/Cr -11% vs -8%, UMOD/Cr -2% vs -7% and albumin/Cr + 17% vs + 13% (all p > 0.05).

Conclusion

In this cohort of adults with CKD, AKI did not associate with long-term changes in urine biomarkers.

Details

Title
Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study
Author
McCoy, Ian E; Hsu, Jesse Y; Bonventre, Joseph V; Parikh, Chirag R; Go, Alan S; Liu, Kathleen D; Ricardo, Ana C; Srivastava, Anand; Cohen, Debbie L; He, Jiang; Chen, Jing; Rao, Panduranga S; Muiru, Anthony N; Chi-yuan, Hsu
Pages
1-8
Section
Research
Publication year
2022
Publication date
2022
Publisher
BioMed Central
e-ISSN
14712369
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2715513468
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.