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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Microfluidics has emerged as a promising alternative for the synthesis of nanoparticles, which ensures precise control over the synthesis parameters, high uniformity, reproducibility, and ease of integration. Therefore, the present study investigated a one-step synthesis and functionalization of magnetite nanoparticles (MNPs) using sulfanilic acid (SA) and 4-sulfobenzoic acid (SBA). The flows of both the precursor and precipitating/functionalization solutions were varied in order to ensure the optimal parameters. The obtained nanoparticles were characterized through dynamic light scattering (DLS) and zeta potential, X-ray diffraction (XRD), selected area electron diffraction (SAED), transmission electron microscopy (TEM) and high-resolution TEM (HR-TEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetry and differential scanning calorimetry (TG-DSC), and vibrating sample magnetometry (VSM). The results demonstrated the successful synthesis of magnetite as the unique mineralogical phase, as well as the functionalization of the nanoparticles. Furthermore, the possibility to control the crystallinity, size, shape, and functionalization degree by varying the synthesis parameters was further confirmed. In this manner, this study validated the potential of the microfluidic platform to develop functionalized MNPs, which are suitable for biomedical and pharmaceutical applications.

Details

Title
Microfluidic Synthesis of -NH2- and -COOH-Functionalized Magnetite Nanoparticles
Author
Chircov, Cristina 1   VIAFID ORCID Logo  ; Bîrcă, Alexandra Cătălina 1 ; Bogdan, Stefan Vasile 2   VIAFID ORCID Logo  ; Oprea, Ovidiu-Cristian 3   VIAFID ORCID Logo  ; Huang, Keng-Shiang 4   VIAFID ORCID Logo  ; Alexandru Mihai Grumezescu 5   VIAFID ORCID Logo 

 Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania 
 Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania; National Research Center for Food Safety, University Politehnica of Bucharest, 060042 Bucharest, Romania 
 National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania 
 The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 840301, Taiwan 
 Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania; Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania; Academy of Romanian Scientists, 54 Splaiul Independentei, 050045 Bucharest, Romania 
First page
3160
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20794991
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2716574287
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.