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Objective: MicroRNAs have been explored as potential biomarkers for many pathological processes including coronary artery disease. In this study, we aimed to compare the circulating levels of selected atherosclerosis-associated miRNAs in patients with a history of early-onset coronary artery disease with that of age- and sex-matched healthy controls and older patients with late-onset coronary artery disease.
Methods: Study population consisted of 30 patients with early onset coronary artery disease, 31 age- and sex-matched healthy controls, and 30 patients with late-onset coronary artery disease. Plasma levels of 13 microRNAs (endothelial cell-related miR-126, -92a/b; vascular smooth muscle cell-related miR-145; inflammation-related miR-16, -21, -125b, -146a/b, -147b, -150, -155; lipometabolism-related miR-27b, -122, -370) were evaluated by using real-time polymerase chain reaction.
Results: In patients with early onset coronary artery disease, plasma expressions of the lipometabolism-related miR-27b, miR-122; inflammation-related miR-125b, miR-146a/b, miR-147b, miR-150, miR-155; and VSMC-related miR-145 were significantly downregulated and endothelial cell-related miR-126 was significantly upregulated compared to age- and sexmatched healthy controls. Circulating microRNA profile of patients with early onset coronary artery disease was also different from that of older patients with late-onset coronary artery disease. Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease.
Conclusion: MicroRNAs are promising biomarkers for early onset coronary artery disease.
Cite this article as: Kahya Eren N, Karaca E, Şirin FB, et al. Does MicroRNA profile differ in early onset coronary artery disease? Turk Kardiyol Dern Ars. 2022;50(6):407-414.
Amaç: MikroRNA’lar (MiRNA), koroner arter hastalığını (KAH) da içeren pek çok patolojik süreçte potansiyel biyobelirteçler olarak araştırılmaktadır. Bu çalışmada, erken başlangıçlı KAH öyküsü olan hastalarda, aterosklerozla ilişkili seçilmiş MiRNA’ların plasma düzeylerini, bu hasta grubuna yaş ve cinsiyet olarak eşleştirilmiş sağlıklı kontrol grubu ve geç başlangıçlı KAH’ı olan daha yaşlı hastalar ile karşılaştırmayı amaçladık.
Yöntemler: Çalışmaya erken başlangıçlı KAH’ı olan 30 hasta, bu hasta grubuna yaş ve cinsiyet açısından eşleştirilmiş 31 sağlıklı kontrol ve geç başlangıçlı KAH’ı olan 30 hasta dahil edildi. On üç MiRNA’nın (endotel hücre ilişkili miR-126, -92a/b; vasküler düz kas hücre ilişkili miR-145; enflamasyonla ilişkili miR-16, -21, -125b, -146a/b, -147b, -150, -155; lipo-metabolizma ile ilişkili miR-27b, -122, -370) dolaşımdaki düzeyleri real-time PCR yöntemi ile değerlendirildi.
Bulgular: Erken başlangıçlı KAH’ı olan hastalarda, yaş ve cinsiyet açısından eşleştirilmiş sağlıklı kontrol grubuna göre lipo-metabolizma ile ilişkili miR-27b, -122, enflamasyonla ilişkili miR125b, miR-146a/b, miR-147b, miR-150, miR-155 ve vasküler düz kas hücre ilişkili miR145’in plasma düzeyleri anlamlı olarak daha düşük, endotel hücre ilişkili miR-126’nın plasma düzeyi ise anlamlı olarak daha yüksekti. Erken başlangıçlı KAH’ı olan hastalarda, dolaşımdaki MiRNA profili geç başlangıçlı KAH’ı olan daha yaşlı hastalara göre de daha farklıydı. Erken başlangıçlı KAH’ı olan hastalarda, geç başlangıçlı KAH’ı olan daha yaşlı hastalara göre miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b ve miR-155’in plasma düzeyleri daha düşük, miR-16 and miR-92a’nın plasma düzeyleri ise daha yüksekti.
Sonuç: MikroRNA’lar erken başlangıçlı KAH için ümit vaat eden biyobelirteçlerdir.
Cite this article as: Kahya Eren N, Karaca E, Şirin FB, et al. Does MicroRNA profile differ in early onset coronary artery disease? Turk Kardiyol Dern Ars. 2022;50(6):407-414.
Title
Does MicroRNA Profile Differ in Early Onset Coronary Artery Disease?
Author
Nihan Kahya Eren; Karaca, Emin; Fevziye Burcu Şirin; Fatih Levent; Gündüz, Cumhur; Özdemir, Emre; Nazlı, Cem; Muhsin Özgür Çoğulu; Asım Oktay Ergene
Publication date
Sep 2022
Aves Yayincilik Ltd. STI.
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2717463276
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