Abstract

Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms.

Details

Title
Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study
Author
Zhang, Jinru 1 ; Chen, Juping 2 ; Li, Jia 3 ; Li, Jian 4 ; Miao, Hong 2 ; Zhu, Xiangyang 3 ; Meng, Meng 4 ; Yang, Han 2 ; Chen, Jing 1 ; Cheng, Xiaoyu 1 ; Xiong Kangping 1 ; Jin, Hong 1 ; Luo Weifeng 1 ; Mao Chengjie 1 ; Liu, Chunfeng 5 

 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China 
 Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China 
 Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China 
 Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China 
 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China 
Pages
1762-1764
Section
Correspondence
Publication year
2022
Publication date
Jul 2022
Publisher
Lippincott Williams & Wilkins Ovid Technologies
ISSN
03666999
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2720852478
Copyright
Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.