Abstract
Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms.
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Details
1 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
2 Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China
3 Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
4 Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China
5 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China