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© 2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”).  Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Sourced from the United States National Library of Medicine® (NLM). This work may not reflect the most current or accurate data available from NLM.

Abstract

Amlexanox, a small molecule targeted therapy which has been used in the treatment of atopic conditions was previously but is not currently available in the United States. Amlexanox has also been legally utilized and administered in Japan as a treatment for asthma, a chronic pulmonary disease characterized by inflammation of the lower respiratory tract. Amlexanox’s immune modulatory effects have been the subject of studies which have repurposed the drug for potential therapeutic applications in metabolic and inflammatory disease. Because amlexanox inhibits TANK-binding kinase1 (TBK1) and nuclear factor kB kinase epsilon (IKKε), several studies have demonstrated its usefulness through its evidence downregulation of the immune system and attenuation of downstream TBK1 signaling. Novel therapies, such as amlexanox, for inflammatory conditions such as asthma will continue to be of value in clinical management. This report summarizes key applications of the drug based on animal and human studies and explores its potential in treatment of metabolic and inflammatory diseases.

Details

Title
Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease
Author
Dosanjh, Amrita; Won, Cindy Y
Pages
759-763
Section
Mini-Review
Publication year
2020
Publication date
Dec 29, 2020
Publisher
Yale Journal of Biology and Medicine
ISSN
00440086
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2724693902
Copyright
© 2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”).  Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Sourced from the United States National Library of Medicine® (NLM). This work may not reflect the most current or accurate data available from NLM.