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Abstract
The comprehensive study of the spatial-cellular anatomy of the human liver is critical to addressing the cellular origins of liver disease. Here we conducted spatial transcriptomics on normal human liver tissue sections, providing detailed information of liver zonation at the transcriptional level. We present 6581 high-quality spots from normal livers of two human donors. In this dataset, cells were mainly hepatocytes, and we classified them into four sub-groups. Collectively, these data provide a reliable reference for studies on spatial heterogeneity of liver lobules.
Measurement(s) | mRNA Expression |
Technology Type(s) | spatial transcriptomics |
Sample Characteristic - Organism | Homo sapiens |
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Details
1 The First Affiliated Hospital of Zhengzhou University, Clinical Systems Biology Laboratories, Translational Medicine Center, Zhengzhou, China (GRID:grid.412633.1) (ISNI:0000 0004 1799 0733); The Affiliated Hospital of Yunnan University, Department of Hepatobiliary Surgery, Kunming, China (GRID:grid.440773.3) (ISNI:0000 0000 9342 2456)
2 The First Affiliated Hospital of Zhengzhou University, Clinical Systems Biology Laboratories, Translational Medicine Center, Zhengzhou, China (GRID:grid.412633.1) (ISNI:0000 0004 1799 0733)
3 The Affiliated Hospital of Yunnan University, Department of Hepatobiliary Surgery, Kunming, China (GRID:grid.440773.3) (ISNI:0000 0000 9342 2456)