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Abstract
Bontia daphnoides L. has been utilized in traditional medicine for treatment of herpes, cough and colds. The aim of this study was to analyze the volatile constituents of this plant by GC/MS (Gas Chromatography coupled to Mass Spectrometry) and to assess their antiviral activity. A total of 64 compounds were identified where dehydroepingaione represented 83.60, 72.36, 58.78 and 34.18% in the leaves, stems, flowers and fruits, respectively. Principal component and hierarchical cluster analysis revealed the discrimination of the organs as the leaves and stems were distributed in the same cluster in contrast to the flowers and fruits. Furthermore, the antiviral activity was assessed where the oils of leaves and stems exhibited potent antiviral activity displaying IC50 of 11.98, 12.62 µg/ml against HSV-1 and 13.34, 14.50 µg/ml against CoxB4, respectively. Dehydroepingaione was isolated from the n-hexane fraction of the leaves and showed activity against HSV-1 and CoxB with IC50 of 24.46 and 25.32 µg/ml, respectively. Molecular modelling studies illustrated that the major compounds showed good affinity towards HSV type-1 thymidine kinase. Therefore, it can be concluded that the oils from B. daphnoides have promising antiviral activity that may be attributed to the major oxygenated sesquiterpenes.
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1 Ain Shams University, Faculty of Pharmacy, Department of Pharmacognosy, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570)
2 Al-Azhar University, Department of Botany and Microbiology, Faculty of Science, Cairo, Egypt (GRID:grid.411303.4) (ISNI:0000 0001 2155 6022)
3 Ain Shams University, Faculty of Pharmacy, Department of Pharmacognosy, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570); Ain Shams University, Center for Drug Discovery Research and Development, Faculty of Pharmacy, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570)