Full text

Turn on search term navigation

© 2017. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objective

Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related to metabolic syndrome (MS).

Materials and Methods

We retrospectively reviewed data from 264 consecutive males who had undergone general health check-ups, including FDG PET/CT scans. After an overnight fast, the men had their peripheral blood drawn and the levels of various laboratory parameters measured; an FDG PET/CT scan was performed on the same day. We measured the maximum standardized uptake values of the brain and liver from regions of interest manually placed over the frontal cortex at the level of the centrum semiovale and the right lobe of the liver parenchyma, respectively.

Results

Fasting blood glucose (FBG; odds ratio [OR] = 1.063, pp = 0.010) were the strongest predictive factors for low brain FDG uptake, whereas waist circumference (OR = 1.200, pp = 0.001) were the strongest predictive factors for high liver uptake. Eleven subjects (4.2%) showed concurrent low brain and high liver FDG uptake, and all but one of these subjects (90.9%) had MS. Systolic blood pressure, waist circumference, FBG, triglyceride, alanine aminotransferase, insulin resistance (measured by homeostasis model assessment), insulin, HbA1c, and body mass index were higher in subjects with this FDG uptake pattern than in those without (all, p

Conclusion

Concurrent low brain and high liver FDG uptake were closely associated with MS. Moreover, subjects with this pattern had higher values for various cardiovascular risk factors than did those without.

Details

Title
Concurrent Low Brain and High Liver Uptake on FDG PET Are Associated with Cardiovascular Risk Factors
Author
Hyun-Yeol Nam; Jun, Sungmin; Pak, Kyoungjune; In Joo Kim
Pages
392-401
Section
Nuclear Medicine
Publication year
2017
Publication date
Mar-Apr 2017
Publisher
The Korean Society of Radiology
ISSN
12296929
e-ISSN
20058330
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2728178819
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.