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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction: Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) has evolved as a treatment for peritoneal carcinomatosis in various tumors after a careful and complete cytoreductive surgery, and it demonstrated much better and longer survival than more traditional therapeutic schemas. Our objective has been to examine the safety, efficacy and survival achieved with closed technique with CO2-agitation system Combat PRS® (Peritoneal Recirculation System: PRS). To achieve this, we compared the appearance of adverse events, mortality and survival with the described using classic techniques (open, closed without CO2-agitation) for the treatment of selected patients with peritoneal carcinomatosis; Materials and methods: We studied overall survival, disease-free survival and safety (morbidity and mortality) of the administration of HIPEC through a closed method technique with CO2 recirculation (Combat PRS®) in 482 patients from 11 Spanish hospitals; Results: The mortality of our technique (1.66%) was similar to other published techniques (open, closed). Morbidity exhibited a 9.96% rate of Clavien-Dindo (CD) III/IV complications in 482 patients, which was lower than in other series. Survival (overall survival (OS) and disease-free survival (DFS)) was similar to previously published results: 86% 1y-OS, 54% 3y-OS, 77% 1y-DFS and 31% 3y-DFS; Conclusion: The procedure with closed PRS with CO2 agitation is as safe as standard open and closed procedures for the administration of HIPEC after complete cytoreductive surgery, with similar and very low mortality (1.66%) and lower morbidity (9.96% CD III and IV in our series vs range of 20–40% in the majority of different series); only Kusamura had similar results, with 12% in 205 patients, using the closed technique without CO2 agitation).

Details

Title
Hyperthermic Intraperitoneal Chemotherapy and Recirculation with CO2: A Safe Technique
Author
Gómez-Sanz, Remedios 1 ; Ovejero-Merino, Enrique 1   VIAFID ORCID Logo  ; Lasa-Unzúe, Inmaculada 2 ; López-García, Adela 2 ; Marcos-Hernández, Ruth 2 ; Mínguez-García, Javier 2 ; Francisca García-Moreno Nisa 2   VIAFID ORCID Logo  ; Mendoza-Moreno, Fernando 2   VIAFID ORCID Logo  ; Díez-Alonso, Manuel 2 ; Ortega, Miguel A 3   VIAFID ORCID Logo  ; Álvarez-Mon, Melchor 4   VIAFID ORCID Logo  ; Gutiérrez-Calvo, Alberto 1 ; Frattini, Milo

 Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain; Spanish Group of Peritoneal Oncologic Surgery (GECOP), Principe de Asturias Teaching Hospital, University of Alcalá de Henares, 28001 Madrid, Spain 
 Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain 
 Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain; Ramón y Cajal Institute of Sanitary Research (IRYCIS), Hospital Universitario Príncipe de Asturias, 28034 Madrid, Spain 
 Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain; Ramón y Cajal Institute of Sanitary Research (IRYCIS), Hospital Universitario Príncipe de Asturias, 28034 Madrid, Spain; Immune System Diseases-Rheumatology and Internal Medicine Service, University Hospital Príncipe de Asturias, (CIBEREHD), 28806 Alcalá de Henares, Spain 
First page
6152
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2728488037
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.