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© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Routine administration of antibacterials in patients with Covid-19 has been a subject of debate, with no solid data about the true prevalence of respiratory coinfections in Covid-19 patients in different geographic areas. The aim of the current study was to identify respiratory coinfections in Covid-19 patients admitted to the hospital and to identify its genetic resistance pattern using the respiratory multiplex polymerase chain reaction (PCR).

Results

The study included 40 patients, 32 males (80%) and 8 (20%) females with a mean age of 59.3 ± 12.6. Half of the patients had respiratory bacterial coinfections documented by pneumonia (PN) panel. The most common isolate was Klebsiella pneumoniae (10/20, 50%), followed by Acinetobacter calcoaceticus baumanni complex (7/20, 35%). Regarding genetic resistance, thirteen (13/20, 65%) isolates were proven extended spectrum beta lactamase (ESBL)-producing Enterobacteriaceae. Thirteen (13/20, 65%) isolates were proven carbapenemase-producing organisms testing positive for New Delhi metallo-β-lactamase (NDM), oxacillinase β-lactamases (OXA-48), and Verona Integron-Encoded Metallo-β-Lactamase (VIM) (7/20, 35%; 5/20, 25%; 1/20, 5%, respectively). The four isolated Staphylococcus aureus were methicillin-resistant (4/20, 20%).

Conclusion

In our cohort, there was 50% rate of bacterial respiratory coinfection in patients with severe Covid-19 admitted to the ICU with high rates of carbapenemase-producing gram-negative bacteria that required escalation of antibacterials and represented a challenge to clinicians.

Details

Title
Respiratory coinfections in COVID-19 patients evaluated by BioFire Pneumonia Panel
Author
Assal, Hebatallah Hany 1   VIAFID ORCID Logo  ; Salah, Maged 2 ; Ibrahim, Ayman Kamal 3 ; Alfishawy, Mostafa 4 ; Khater, Rawia 5 ; Masoud, Hossam Hosny 1 ; Eldemerdash, Ahmed Monier 6 ; AbdelHalim, Mohamed Ali 2 

 Cairo University, Department of Chest Medicine, Faculty of Medicine, Cairo, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
 Cairo University, Department of Anaethesia, Faculty of Medicine, Cairo, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
 Misr International Hospital, Laboratory Department, Cairo, Egypt (GRID:grid.7776.1) 
 Infectious Diseases Consultants and Academic Researchers of Egypt (IDCARE), Cairo, Egypt (GRID:grid.7776.1) 
 Cairo University, Internal Medicine department, Faculty of Medicine, Cairo, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
 Ain Shams University, Intensive Care Department, Faculty of Medicine, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570) 
Publication year
2021
Publication date
Dec 2021
Publisher
Springer Nature B.V.
ISSN
16878426
e-ISSN
23148551
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2730345255
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.