Abstract

Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.

Details

Title
In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways
Author
Misik, Ondrej; Lizal, Frantisek; Malý, Milan; Karas, Jakub; Jedelsky, Jan; Jicha, Miroslav
Section
Contributions
Publication year
2022
Publication date
2022
Publisher
EDP Sciences
ISSN
21016275
e-ISSN
2100014X
Source type
Conference Paper
Language of publication
English
ProQuest document ID
2730640209
Copyright
© 2022. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.