In vitro antifungal and antibacterial potentials of organic extracts of Avicennia marina collected from Rabigh Lagoon, Red Sea Coasts in Saudi Arabia

Abstract

Arbusto de mangue Avicennia marina (Forsk.) Vierh foi usado para testar as atividades antifúngicas e antibacterianas de fraçoes aéreas in vitro. As bacterias Aspergillus sp, Candida sp e Gram-positivas mostraram-se sensíveis aos extratos de mangue, enquanto as bacterias Gram-negativas mostraram-se resistentes a eles. Difusäo em disco de ágar e difusäo bem cortada foram empregadas para realizar atividades antifúngicas e antibacterianas. Para cada ensaio foram estabelecidas as CIMs (concentrares inibitórias mínimas). Vários extratos de mangue reduziram o crescimento do fungo (os diámetros variaram entre 11 e 41 mm). A fraçâo acetato de etila mostrou inibiçâo particularmente forte de C. tropicalis, C. albicanis e A. fumigatus. Eles tinham zonas de inibiçâo de 41, 40 e 25 mm de diámetro, respectivamente. Nesoral, um medicamento antifúngico sintético, näo apresentou alteraçoes significativas em suas CIMs em comparaçâo com diferentes extratos Enterococcus faecalis e Bacillus subtilis foram inibidos por extratos de éter de petróleo em MICs de 0,78 e 0,35 mg/mL, respectivamente. É possível que os extratos de A. marina possam ser explorados como uma alternativa natural viável que pode ser empregada no manejo de várias infecçöes, notadamente infecçöes bacterianas nosocomiais, como agentes anti-candidíase e anti-aspergilose.

Alternate abstract:

Mangrove shrub Avicennia marina (Forsk.) Vierh was used to test the antifungal and antibacterial activities of aerial fractions in vitro. Aspergillus sp, Candida sp and Gram positive bacteria have all been found to be sensitive to mangrove extracts, whereas Gram negative bacteria have been found to be resistant to them. Agar disc diffusion and well-cut diffusion were employed to conduct antifungal and antibacterial activities. The MICs (minimum inhibitory concentrations) for each assay have been established. Several extracts from Mangrove reduced fungus growth (diameters fluctuated between 11 and 41 mm). The Ethyl acetate fraction showed particularly strong inhibition of C. tropicalis, C. albicanis, and A. fumigatus. They had 41, 40, and 25 mm-diameter inhibition zones, respectively. Nesoral, a synthetic antifungal medication, showed no significant changes in its MICs compared to different extracts. Enterococcus faecalis and Bacillus subtilis were inhibited by Petroleum Ether extracts at MICs of 0.78 and 0.35 mg/mL, respectively. It is possible that A. marina extracts may be exploited as a viable natural alternative that may be employed in the management of various infections, notably nosocomial bacterial infections, as anti-candidiasis and as anti-aspergillosis agents.