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Abstract
Placentas of obese women have low mitochondrial β-oxidation of fatty acids (FA) and accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing placental efficiency. We hypothesized that placental FA metabolism is impaired in women with obesity from early pregnancy. We assessed expression of key regulators of FA metabolism in first trimester placentas of lean and obese women. Maternal fasting triglyceride and insulin levels were measured in plasma collected at the time of procedure. Expression of genes associated with FA oxidation (FAO; ACOX1, CPT2, AMPKα), FA uptake (LPL, LIPG, MFSD2A), FA synthesis (ACACA) and storage (PLIN2) were significantly reduced in placentas of obese compared to lean women. This effect was exacerbated in placentas of male fetuses. Placental ACOX1 protein was higher in women with obesity and correlated with maternal circulating triglycerides. The PPARα pathway was enriched for placental genes impacted by obesity, and PPARα antagonism significantly reduced 3H-palmitate oxidation in 1st trimester placental explants. These results demonstrate that obesity and hyperlipidemia impact placental FA metabolism as early as 7 weeks of pregnancy.
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Details
1 Mother Infant Research Institute, Tufts Medical Center, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045)
2 Brandon Regional Hospital, Brandon, USA (GRID:grid.67033.31)
3 Tufts University School of Medicine, Department of Obstetrics and Gynecology, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045)
4 Boston University School of Medicine, Department of Obstetrics and Gynecology, Boston, USA (GRID:grid.189504.1) (ISNI:0000 0004 1936 7558)
5 Mother Infant Research Institute, Tufts Medical Center, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045); Tufts University School of Medicine, Department of Obstetrics and Gynecology, Boston, USA (GRID:grid.67033.31) (ISNI:0000 0000 8934 4045); Tufts University, Friedman School of Nutrition, Boston, USA (GRID:grid.429997.8) (ISNI:0000 0004 1936 7531)