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Abstract
Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA—PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA—PSPMA). The as-prepared h-SiO2/PDA—PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA—PSPMA coating and “rolling” effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA—PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA—PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.
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Details
1 Northwest Normal University, Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou, China (GRID:grid.412260.3) (ISNI:0000 0004 1760 1427)
2 Northwest Normal University, Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou, China (GRID:grid.412260.3) (ISNI:0000 0004 1760 1427); Chinese Academy of Sciences, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Lanzhou, China (GRID:grid.9227.e) (ISNI:0000000119573309)
3 Chinese Academy of Sciences, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Lanzhou, China (GRID:grid.9227.e) (ISNI:0000000119573309); Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai, China (GRID:grid.9227.e)
4 Chinese Academy of Sciences, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Lanzhou, China (GRID:grid.9227.e) (ISNI:0000000119573309)