Abstract

Graph representation learning is a method for introducing how to effectively construct and learn patient embeddings using electronic medical records. Adapting the integration will support and advance the previous methods to predict the prognosis of patients in network models. This study aims to address the challenge of implementing a complex and highly heterogeneous dataset, including the following: (1) demonstrating how to build a multi-attributed and multi-relational graph model (2) and applying a downstream disease prediction task of a patient’s prognosis using the HinSAGE algorithm. We present a bipartite graph schema and a graph database construction in detail. The first constructed graph database illustrates a query of a predictive network that provides analytical insights using a graph representation of a patient’s journey. Moreover, we demonstrate an alternative bipartite model where we apply the model to the HinSAGE to perform the link prediction task for predicting the event occurrence. Consequently, the performance evaluation indicated that our heterogeneous graph model was successfully predicted as a baseline model. Overall, our graph database successfully demonstrated efficient real-time query performance and showed HinSAGE implementation to predict cardiovascular disease event outcomes on supervised link prediction learning.

Details

Title
Heterogeneous graph construction and HinSAGE learning from electronic medical records
Author
Cho, Ha Na 1 ; Ahn, Imjin 2 ; Gwon, Hansle 2 ; Kang, Hee Jun 1 ; Kim, Yunha 2 ; Seo, Hyeram 2 ; Choi, Heejung 2 ; Kim, Minkyoung 2 ; Han, Jiye 2 ; Kee, Gaeun 1 ; Jun, Tae Joon 3 ; Kim, Young-Hak 1 

 University of Ulsan College of Medicine, Division of Cardiology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667) 
 University of Ulsan College of Medicine, Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667) 
 Asan Medical Center, Big Data Research Center, Asan Institute for Life Sciences, Seoul, Republic of Korea (GRID:grid.413967.e) (ISNI:0000 0001 0842 2126) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2747549686
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.