Abstract

Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes.

Details

Title
Confirmation of fifth Candida auris clade by whole genome sequencing
Author
Spruijtenburg, Bram 1   VIAFID ORCID Logo  ; Badali, Hamid 2   VIAFID ORCID Logo  ; Abastabar, Mahdi 3   VIAFID ORCID Logo  ; Mirhendi, Hossein 4   VIAFID ORCID Logo  ; Khodavaisy, Sadegh 5   VIAFID ORCID Logo  ; Sharifisooraki, Joobin 6 ; Mojtaba Taghizadeh Armaki 7   VIAFID ORCID Logo  ; de Groot, Theun 1   VIAFID ORCID Logo  ; Meis, Jacques F 8   VIAFID ORCID Logo 

1  Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands; Centre of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, Netherlands 
2  Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA 
3  Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran 
4  Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 
5  Faculty of Public Health, Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran 
6  Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari, Iran 
7  Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran 
8  Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands; Centre of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, Netherlands; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands 
Pages
2405-2411
Publication year
2022
Publication date
Dec 2022
Publisher
Taylor & Francis Ltd.
e-ISSN
22221751
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/22221751.2022.2125349
ProQuest document ID
2748036959
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.