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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The prevalence of type 2 diabetes mellitus (T2D) is alarmingly increasing worldwide, urgently calling for a better understanding of the underlying mechanisms in order to step up prevention and improve therapeutic approaches. It is becoming evident that the gut microbiota seem to have an endless capacity to impact T2D. In this study, we profile the gut microbiome patterns in T2D patients from Romania, by using quantitative Real-Time PCR and next generation sequencing. We enrolled a total of 150 individuals (105 T2D patients, 50 of them without metformin treatment and 45 healthy volunteers). The levels of potentially beneficial butyrate-producing bacteria were significantly reduced, while potentially pathogenic microorganisms such as Enterobacteriaceae and Fusobacterium were enriched in T2D patients. We evaluated the correlation between clinical parameters and gut microbiota and identified the genera Bacteroides, Alistipes, Dialister, Bilophila and Sutterella as possible detrimental factors in T2D. Our findings suggest that the gut microbiota may be a potential target in novel approaches to halt the development of T2D-associated complications.

Details

Title
Snapshot into the Type-2-Diabetes-Associated Microbiome of a Romanian Cohort
Author
Pircalabioru, Gratiela Gradisteanu 1 ; Mariana-Carmen Chifiriuc 2   VIAFID ORCID Logo  ; Picu, Ariana 3 ; Petcu, Laura Madalina 3 ; Trandafir, Maria 4 ; Savu, Octavian 5 

 Research Institute of University of Bucharest (ICUB), 050095 Bucharest, Romania; [email protected]; Academy of Romanian Scientists, 050045 Bucharest, Romania 
 Research Institute of University of Bucharest (ICUB), 050095 Bucharest, Romania; [email protected]; Academy of Romanian Scientists, 050045 Bucharest, Romania; Romanian Academy, 010071 Bucharest, Romania; Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania 
 “N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 020042 Bucharest, Romania; [email protected] (A.P.); [email protected] (L.M.P.); [email protected] (O.S.) 
 Department of Doctoral School, “Carol Davila” University of Medicine and Pharmacy, 5th District, 050474 Bucharest, Romania; [email protected] 
 “N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 020042 Bucharest, Romania; [email protected] (A.P.); [email protected] (L.M.P.); [email protected] (O.S.); Department of Doctoral School, “Carol Davila” University of Medicine and Pharmacy, 5th District, 050474 Bucharest, Romania; [email protected] 
First page
15023
Publication year
2022
Publication date
2022
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2748548102
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.