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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Edentulism is the condition of having lost natural teeth, and has serious social, psychological, and emotional consequences. The need for implant services in edentulous patients has dramatically increased during the last decades. In this study, the effects of concentrated growth factor (CGF), an autologous blood-derived biomaterial, in improving the process of osseointegration of dental implants have been evaluated. Here, permeation of dental implants with CGF has been obtained by using a Round up device. These CGF-coated dental implants retained a complex internal structure capable of releasing growth factors (VEGF, TGF-β1, and BMP-2) and matrix metalloproteinases (MMP-2 and MMP-9) over time. The CGF-permeated implants induced the osteogenic differentiation of human bone marrow stem cells (hBMSC) as confirmed by matrix mineralization and the expression of osteogenic differentiation markers. Moreover, CGF provided dental implants with a biocompatible and biologically active surface that significantly improved adhesion of endothelial cells on CGF-coated implants compared to control implants (without CGF). Finally, data obtained from surgical interventions with CGF-permeated dental implants presented better results in terms of optimal osseointegration and reduced post-surgical complications. These data, taken together, highlight new and interesting perspectives in the use of CGF in the dental implantology field to improve osseointegration and promote the healing process.

Details

Title
Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation
Author
Palermo, Andrea 1   VIAFID ORCID Logo  ; Giannotti, Laura 2 ; Benedetta Di Chiara Stanca 2   VIAFID ORCID Logo  ; Ferrante, Franco 3   VIAFID ORCID Logo  ; Gnoni, Antonio 4 ; Nitti, Paola 5   VIAFID ORCID Logo  ; Calabriso, Nadia 6   VIAFID ORCID Logo  ; Demitri, Christian 5   VIAFID ORCID Logo  ; Damiano, Fabrizio 2   VIAFID ORCID Logo  ; Batani, Tiziano 7 ; Lungherini, Massimo 7 ; Maria Annunziata Carluccio 6   VIAFID ORCID Logo  ; Rapone, Biagio 8   VIAFID ORCID Logo  ; Qorri, Erda 9   VIAFID ORCID Logo  ; Scarano, Antonio 10   VIAFID ORCID Logo  ; Siculella, Luisa 2   VIAFID ORCID Logo  ; Stanca, Eleonora 2 ; Rochira, Alessio 2 

 College of Medicine and Dentistry Birmingham, University of Birmingham, Birmingham B4 6BN, UK 
 Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy 
 Independent Researcher, 73100 Lecce, Italy 
 Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, 70121 Bari, Italy 
 Department of Engineering for Innovation, Campus Ecotekne, University of Salento, Via per Monteroni, 73100 Lecce, Italy 
 National Research Council (CNR) Institute of Clinical Physiology (IFC), 73100 Lecce, Italy 
 Silfradent srl, via A. Moro, 22, 73100 Lecce, Italy 
 Interdisciplinary Department of Medicine, Aldo Moro University of Bari, 70121 Bari, Italy 
 Faculty of Medical Science, Albanian University, Bulevardi Zogu I, 1001 Tirana, Albania 
10  Department of Oral Science, Nano and Biotechnology and CeSi-Met, University of Chieti-Pescara, 66100 Chieti, Italy 
First page
15164
Publication year
2022
Publication date
2022
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2748549240
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.