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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam.

Details

Title
Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors
Author
Tran Thanh Tung 1 ; Schmid, Jürgen 2 ; Vu Xuan Nghia 3 ; Cao, Le Chi 4   VIAFID ORCID Logo  ; Le Thi Kieu Linh 1 ; Rungsung, Ikrormi 2 ; Bui, Tien Sy 5 ; Truong Nhat My 6 ; Nguyen Trong The 7   VIAFID ORCID Logo  ; Nghiem, Xuan Hoan 7   VIAFID ORCID Logo  ; Meyer, Christian G 1   VIAFID ORCID Logo  ; Wedemeyer, Heiner 8 ; Kremsner, Peter G 9 ; Nguyen, Linh Toan 10 ; Song, Le Huu 7 ; C-Thomas, Bock 11   VIAFID ORCID Logo  ; Velavan, Thirumalaisamy P 1 

 Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, Vietnam 
 Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany 
 108 Military Central Hospital, Hanoi 10000, Vietnam 
 Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany; Department of Parasitology, Hue University of Medicine and Pharmacy (HUMP), Hue 52000, Vietnam 
 Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany; 108 Military Central Hospital, Hanoi 10000, Vietnam 
 Vietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, Vietnam 
 Vietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, Vietnam; 108 Military Central Hospital, Hanoi 10000, Vietnam 
 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany; German Center for Infection Research, Partner Hannover-Braunschweig, 38104 Braunschweig, Germany 
 Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany; Centre de Recherches Medicales de Lambarene, Lambaréné B.P. 242, Gabon 
10  Department of Pathophysiology, Vietnam Military Medical University, Hanoi 10000, Vietnam 
11  Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany; Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany 
First page
1524
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20760817
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2756755248
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.