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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

We assessed SARS-CoV-2 anti-spike immunoglobulin G (anti-S-IgG) levels among healthcare workers (HCWs) after BNT162b2 vaccination. The anti-S-IgG titers of study participants were measured every three months, a week before, and three weeks after each vaccination. This study compared the short-term immune response to the second vaccination in four HCWs who received the first two doses six months apart (due to acute allergic-like adverse events after the first dose), with that of six HCWs who received the first two doses three weeks apart, according to the standard schedule. The four HCWs who experienced acute allergic-like adverse events after the first vaccination took antihistamines before the second vaccination. None of them experienced an allergic-like reaction after the second vaccination, and the short-term immune response to the second vaccination was similar in both groups.

Details

Title
Good Immunogenicity of Delayed Second Dose of BNT162b2 Vaccine in Individuals with Acute Allergic-like Reactions after the First Dose
Author
Araki, Kazuhiro 1   VIAFID ORCID Logo  ; Shimizu, Nobuaki 2 ; Iijima, Misa 3 ; Hosaka, Hisashi 4 ; Yanagita, Yasuhiro 5 

 Department of Medical Oncology, Gunma Prefectural Cancer Center, Ota City 373-8550, Gunma, Japan 
 Department of Urology, Gunma Prefectural Cancer Center, Ota City 373-8550, Gunma, Japan 
 Department of Pathology, Gunma Prefectural Cancer Center, Ota City 373-8550, Gunma, Japan 
 Department of Gastrointestinal Medicine, Gunma Prefectural Cancer Center, Ota City 373-8550, Gunma, Japan 
 Department of Breast Oncology, Gunma Prefectural Cancer Center, Ota City 373-8550, Gunma, Japan 
First page
48
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
2571841X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2756779015
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.