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Abstract
We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA–mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. miRNA–mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.
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1 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354); University of South Alabama, Department of Pathology, Mobile, USA (GRID:grid.267153.4) (ISNI:0000 0000 9552 1255)
2 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354)
3 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354); Ahmadu Bello University, Department of Biochemistry, Faculty of Life Sciences, Zaria, Nigeria (GRID:grid.411225.1) (ISNI:0000 0004 1937 1493)
4 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354); Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh (GRID:grid.466521.2) (ISNI:0000 0001 2034 6517)
5 University of South Alabama, Department of Pathology, Mobile, USA (GRID:grid.267153.4) (ISNI:0000 0000 9552 1255)
6 The Ohio State University, Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, Columbus, USA (GRID:grid.261331.4) (ISNI:0000 0001 2285 7943)
7 Weill Cornell Medicine, Department of Surgery, New York, USA (GRID:grid.5386.8) (ISNI:000000041936877X)
8 The University of Alabama at Birmingham, Department of Pathology, Birmingham, USA (GRID:grid.265892.2) (ISNI:0000000106344187)
9 China Medical University, Graduate Institute of Biomedical Sciences and Research Center for Cancer Biology, Taichung, Taiwan (GRID:grid.254145.3) (ISNI:0000 0001 0083 6092)
10 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354); Piedmont Hospital, Department of Hematology/Oncology, Newnan, USA (GRID:grid.414991.0) (ISNI:0000 0000 8868 0557)
11 Tuskegee University, Department of Biology and Center for Cancer Research, Tuskegee, USA (GRID:grid.265253.5) (ISNI:0000 0001 0707 9354); Johns Hopkins School of Medicine, Department of Pathology, Baltimore, USA (GRID:grid.21107.35) (ISNI:0000 0001 2171 9311); Johns Hopkins University School of Medicine, Cancer Genetics and Epigenetics, Sidney Kimmel Comprehensive Cancer Center, Baltimore, USA (GRID:grid.21107.35) (ISNI:0000 0001 2171 9311); Johns Hopkins University School of Medicine, Department of Urology, Baltimore, USA (GRID:grid.21107.35) (ISNI:0000 0001 2171 9311)