Abstract

Background

No previous research has investigated the direct effects of exercise interventions on COVID-19 outcomes. The aim is to investigate the effect of 8 weeks of home-based moderate-intensity continuous training (MICT), resistance training (RT), and combined aerobic and resistance training (CET) on biochemical and hematologic markers associated with COVID-19 symptoms and severity in COVID-19 survivors.

Methods

A total of 547 male and female COVID-19 survivors were screened, and 296 (aged 20–93 years) were randomly assigned in a 1:1:1:1 ratio to one of four groups: MICT (n = 74), RT (n = 74), CET (n = 74), or non-exercise (NON-EX, n = 74). Blood samples were taken at baseline, at week 4, and week 8 after training.

Results

After the intervention, compared with the NON-EX group, all 3 MICT, RT, and CET interventions caused significant improvements in the levels of creatine kinase (CK), lactate dehydrogenase (LDH), C-reactive protein (CRP), troponin-I, d-dimer, creatinine, urea, potassium (K), sodium (Na), white blood cell (WBC), neutrophils, lymphocytes, red blood cells (RBC), platelets, hemoglobin, and hematocrit concentrations (P < 0.05). CET was effectively superior to MICT and RT in the improvements in the biochemical and hematological variables studied (P < 0.05).

Conclusions

Overall, the present study demonstrates that long-term MICT plus RT interventions have a synergistic effect in accelerating and enhancing the recovery in patients surviving COVID-19.

Trial registration IRCT20160605028270N3, 6 September 2020.

Details

Title
The Effects of Exercise Training on Recovery of Biochemical and Hematological Outcomes in Patients Surviving COVID-19: A Randomized Controlled Assessor-Blinded Trial
Author
Tartibian, Bakhtyar 1 ; Khayat, Sirwan Mohammad Amini 2 ; Maleki, Behzad Hajizadeh 3 ; Chehrazi, Mohammad 4   VIAFID ORCID Logo 

1  Allameh Tabataba’i University, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tehran, Iran (GRID:grid.444893.6) (ISNI:0000 0001 0701 9423) 
2  Urmia University, Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia, Iran (GRID:grid.412763.5) (ISNI:0000 0004 0442 8645) 
3  Justus-Liebig-University, Department of Exercise Physiology and Sports Therapy, Giessen, Germany (GRID:grid.8664.c) (ISNI:0000 0001 2165 8627) 
4  Babol University of Medical Sciences, Department of Biostatistics and Epidemiology School of Public Health, Babol, Iran (GRID:grid.411495.c) (ISNI:0000 0004 0421 4102) 
Pages
152
Publication year
2022
Publication date
Dec 2022
Publisher
Springer Nature B.V.
ISSN
21991170
e-ISSN
21989761
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40798-022-00546-4
ProQuest document ID
2757228598
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.