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Copyright © 2022 Milton Amaral Pereira et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

The objective of this study was to verify the influence of the ACTN3 R577X polymorphism on muscle damage and the inflammatory response after an acute strength training (ST) session. Twenty-seven healthy male individuals (age: 25±4.3 years) participated in the study, including 18 RR/RX and 9 XX individuals. The participants were divided into two groups (RR/RX and XX groups) and subjected to an acute ST session, which consisted of a series of leg press, leg extension machine, and seated leg curl machine. The volunteers were instructed to perform the greatest volume of work until concentric muscle failure. Each volunteer’s performance was analyzed as the load and total volume of training, and the blood concentrations of C-C motif chemokine ligand 2 (CCL2), interleukin-8 (IL-8), creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, testosterone, and cortisol were measured before the ST session and 30 min and 24 h postsession. The ACTN3 R577X polymorphism effect was observed, with increased concentrations of CCL2 (p<0.01), IL-8 (p<0.01), and LDH (p<0.001) in XX individuals. There was an increase in the concentration of CK in the RR/RX group compared to XX at 24 h after training (p>0.01). The testosterone/cortisol ratio increased more markedly in the XX group (p<0.001). Regarding performance, the RR/RX group presented higher load and total volume values in the training exercises when compared to the XX group (p<0.05). However, the XX group presented higher values of delayed onset muscle soreness (DOMS) than the RR/RX group (p<0.05). The influence of ACTN3 R577X polymorphism on muscle damage and the inflammatory response was observed after an acute ST session, indicating that the RR/RX genotype shows more muscle damage and a catabolic profile due to a better performance in this activity, while the XX genotype shows more DOMS.

Details

Title
Influence of Alpha-Actinin-3 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session
Author
Milton Amaral Pereira 1 ; Izinara Cruz Rosse 2   VIAFID ORCID Logo  ; Silva, Ana Carolina 1   VIAFID ORCID Logo  ; Pedro José Fernandes Nunes Coelho 1   VIAFID ORCID Logo  ; Magalhães de Castro, Bruno 1   VIAFID ORCID Logo  ; Lenice Kappes Becker 3 ; João Batista Ferreira Júnior 4   VIAFID ORCID Logo  ; Cruz de Oliveira, Emerson 3   VIAFID ORCID Logo  ; Kelerson Mauro de Castro Pinto 5   VIAFID ORCID Logo  ; Talvani, André 6   VIAFID ORCID Logo  ; Karina Barbosa de Queiroz 7   VIAFID ORCID Logo  ; Daniel Barbosa Coelho 3   VIAFID ORCID Logo 

 Health and Nutrition Postgraduate Program, Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil 
 Department of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil 
 Program in Health and Nutrition, School of Physical Education, Exercise Physiology Laboratory, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil 
 Department of Physical Education, Federal Institute of Sudeste of Minas Gerais, Rio Pomba, Minas Gerais, Brazil 
 School of Physical Education, Exercise Physiology Laboratory, Inflammation Immunobiology Laboratory, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil 
 Department of Biological Sciences, Federal University of Ouro Preto, Health and Nutrition Program, Ouro Preto, Minas Gerais, Brazil 
 Department of Nutrition, Federal University of Ouro Preto, Health and Nutrition Postgraduate Program, Ouro Preto, Minas Gerais, Brazil 
Editor
Georgian Badicu
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2758026739
Copyright
Copyright © 2022 Milton Amaral Pereira et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/