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Abstract
A study on 51 SNPs belonging to 29 genes related to heat stress was carried out in 720 sheep from 17 different breeds adapted to different climates from Hungary, Bosnia and Herzegovina, Morocco and Romania, using Kompetitive Allele-Specific Polymerase Chain Reaction. Genotype frequency and the Hardy–Weinberg equilibrium were calculated, followed by a clustering using the Principal Component Analysis. We analyzed the polymorphisms in the following genes analyzed: HSPA12A,HSP90AA1,IL33,DIO2,BTNL2,CSN2,ABCG1,CSN1S1,GHR,HSPA8,STAT3, and HCRT. We emphasized on HSPA12A and HSPA8 genes as they were successfully genotyped in all studied flocks in which genotype frequency patterns were identified. Contrary to previous findings, the A allele for HSPA8 SNP was not observed in the heat tolerant breeds, being found exclusively in cold-tolerant breeds. The principal component analysis could not clearly differentiate the breeds, while plot concentration was slightly varied among the three groups, with HSP90AA1 and IL33 SNPs’ loading values significantly contributing to PC1 and PC2. We confirmed previous works that the HSPA12A,HSPA8,HSP90AA1 and IL33 SNPs are potential candidate markers for thermotolerance adaptation in sheep. This research contributes to the genetic variability of SNPs for thermotolerance adaptability in sheep.
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1 University of Debrecen, Centre of Agricultural Genomics and Biotechnology, Debrecen, Hungary (GRID:grid.7122.6) (ISNI:0000 0001 1088 8582); University of Debrecen, Doctoral School of Animal Science, Debrecen, Hungary (GRID:grid.7122.6) (ISNI:0000 0001 1088 8582)
2 Research and Development Station for Bovine, Arad, Romania (GRID:grid.7122.6)
3 Research and Development Institute for Bovine Balotesti, Balotesti, Romania (GRID:grid.7122.6)
4 Mohammed V University in Rabat, Morocco and African Sustainable Agriculture Research Institute (ASARI), Mohammed VI Polytechnic University (UM6P), Laâyoune, Morocco (GRID:grid.31143.34) (ISNI:0000 0001 2168 4024)
5 University of Sarajevo, Veterinary Faculty, Department of Physiology, Sarajevo, Bosnia and Herzegovina (GRID:grid.11869.37) (ISNI:0000000121848551)
6 University of Debrecen, Centre of Agricultural Genomics and Biotechnology, Debrecen, Hungary (GRID:grid.7122.6) (ISNI:0000 0001 1088 8582)