Full text

Turn on search term navigation

© 2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

Few studies have investigated how neuroinflammation early in the disease course may affect Alzheimer's disease (AD) progression over time despite evidence that neuroinflammation is associated with AD.

Methods

Research participants with cerebrospinal fluid (CSF) biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were included in this study. Cox models were used to investigate whether baseline CSF neuroinflammation was associated with incident mild cognitive impairment (MCI) or AD. Moderating effects of sex and apolipoprotein E (APOE) ε4 were also examined.

Results

Elevated levels of tumor necrosis factor α (TNF-α), interleukin (IL)-9, and IL-12p40 at baseline were associated with higher rates of conversion to MCI/AD. Interactions with sex and APOE ε4 were observed, such that women with elevated TNF-α and all APOE ε4 carriers with elevated IL-9 levels had shorter times to conversion. In addition, TNF-α mediated the relationship between elevated IL-12p40 and IL-9.

Discussion

Elevated neuroinflammation markers are associated with incident MCI/AD, and the factors of sex and APOE ε4 status modify the time to conversion.

Details

Title
Higher baseline levels of CSF inflammation increase risk of incident mild cognitive impairment and Alzheimer's disease dementia
Author
Contreras, Joey A 1   VIAFID ORCID Logo  ; Aslanyan, Vahan 2   VIAFID ORCID Logo  ; Albrecht, Daniel S 3 ; Mack, Wendy J 4 ; Pa, Judy 1   VIAFID ORCID Logo 

 Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, University of California, San Diego, California, USA; Mark and Mary Stevens Neuroimaging and Informatics Institute, Department of Neurology, University of Southern California, Los Angeles, California, USA 
 Mark and Mary Stevens Neuroimaging and Informatics Institute, Department of Neurology, University of Southern California, Los Angeles, California, USA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA 
 Mark and Mary Stevens Neuroimaging and Informatics Institute, Department of Neurology, University of Southern California, Los Angeles, California, USA 
 Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA 
Section
FLUID BIOMARKERS
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
e-ISSN
23528729
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2758363446
Copyright
© 2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.