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© 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Hypermetabolism following severe burn injuries is associated with adipocyte dysfunction, elevated beige adipocyte formation, and increased energy expenditure. The resulting catabolism of adipose leads to detrimental sequelae such as fatty liver, increased risk of infections, sepsis, and even death. While the phenomenon of pathological white adipose tissue (WAT) browning is well-documented in cachexia and burn models, the molecular mechanisms are essentially unknown. Here, we report that adipose triglyceride lipase (ATGL) plays a central role in burn-induced WAT dysfunction and systemic outcomes. Targeting adipose-specific ATGL in a murine (AKO) model resulted in diminished browning, decreased circulating fatty acids, and mitigation of burn-induced hepatomegaly. To assess the clinical applicability of targeting ATGL, we demonstrate that the selective ATGL inhibitor atglistatin mimics the AKO results, suggesting a path forward for improving patient outcomes.

Details

Title
Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice
Author
Kaur, Supreet 1 ; Auger, Christopher 1 ; Barayan, Dalia 2 ; Shah, Priyal 3 ; Matveev, Anna 1 ; Knuth, Carly M 2 ; Harris, Thurl E 4 ; Jeschke, Marc G 2   VIAFID ORCID Logo 

 Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada 
 Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada 
 Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada 
 Department of Pharmacology, University of Virginia School of Medicine, Charlottesville VA, USA 
Section
RESEARCH ARTICLES
Publication year
2021
Publication date
Jun 2021
Publisher
John Wiley & Sons, Inc.
e-ISSN
20011326
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2760819081
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.