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© 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

[...]we aimed to explore potential differences in specific dysbiosis in the gut-mucosal microbiome, comparing biopsies from two different locations (ileum and caecum), of HIV-infected subjects with different clinical phenotypes. SEE PDF] Sequencing data of 16S rRNA from the microbiota present in terminal ileum and caecum samples of study subjects were analysed and compared with bacterial taxonomic databases. [...]parameters of richness and alpha-diversity of the gut microbiome showed no statistically significant differences between healthy and HIV-groups (elite controller [EC], early-treated [ET], late-treated high recovery [LT-HR] and late-treated low recovery [LT-LR]) regardless the biopsied intestinal area (Figure 2A) or patient sex (Figure S1). [...]abundance analyses were performed without separating by gut location. [...]this is the first report to analyse the potential association of the clinical phenotype of HIV-subjects, regarding their CD4 status at cART onset and afterwards, with alterations in the microbiome composition.

Details

Title
Partial restoration of gut-mucosal dysbiosis in late-treated HIV-infected subjects with CD4 T-cell recovery
Author
Olivas-Martínez, Israel 1 ; Rosado-Sánchez, Isaac 1 ; Cordero-Varela, Juan Antonio 2 ; Sobrino, Salvador 3 ; Genebat, Miguel 1 ; Herrero-Fernández, Inés 1 ; Rocío Martínez de Pablos 4 ; Carvajal, Ana Eloísa 4 ; Ruiz, Rocío 4 ; Álvarez-Ríos, Ana Isabel 5 ; Fontillón-Alberdi, María 6 ; Bulnes-Ramos, Ángel 1 ; Garrido-Rodríguez, Vanesa 1 ; María del Mar Pozo-Balado 1 ; Leal, Manuel 7 ; Pacheco, Yolanda María 1   VIAFID ORCID Logo 

 Immunology Lab, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain 
 Bioinformatics and Computational Biology Service, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain 
 Digestive Service, University Hospital Virgen del Rocío, Seville, Spain 
 Biochemistry and Molecular Biology Department, Pharmacy, University of Seville, Spain; Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain 
 Biochemistry Service, University Hospital Virgen del Rocío, Seville, Spain 
 Service of Pathological Anatomy, University Hospital Virgen del Rocío, Seville, Spain 
 Internal Medicine Service, Viamed-Santa Ángela Hospital, Seville, Spain 
Section
LETTER TO EDITOR
Publication year
2022
Publication date
Apr 2022
Publisher
John Wiley & Sons, Inc.
e-ISSN
20011326
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2760827272
Copyright
© 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.