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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This work aims to depth-resolved quantitatively analyze the effect of different stromal ablation amounts on the corneal biomechanical properties during small incision lenticule extraction (SMILE) using optical coherence elastography (OCE). A 4.5-MHz ultrasonic transducer was used to excite elastic waves in the corneal tissue. The OCE system combined with the antisymmetric Lamb wave model was employed to achieve a high-resolution, high-sensitivity, and depth-resolved quantitative detection of the corneal Young’s modulus. Eighteen rabbits were randomly divided into three groups; each group had six rabbits. The first and second groups underwent -3D and -6D SMILE surgeries, and the third group was the control group, respectively. Young’s modulus of the corneal cap and residual stromal bed (RSB) were both increased after SMILE, which shared the stress under intraocular pressure (IOP). Furthermore, the Young’s modulus of both the corneal cap and RSB after 3D SMILE group were significantly lower than that in the -6D group, which indicated that the increases in the post-operative corneal Young’s modulus were positively correlated with the amount of stromal ablation. The OCE system for quantitative spatial characterization of corneal biomechanical properties can provide useful information on the extent of safe ablation for SMILE procedures.

Details

Title
In Vivo Evaluation of the Effects of SMILE with Different Amounts of Stromal Ablation on Corneal Biomechanics by Optical Coherence Elastography
Author
Zhu, Yirui 1   VIAFID ORCID Logo  ; Zhao, Yanzhi 2 ; Zhang, Yubao 3 ; Yang, Hongwei 2 ; Shi, Jiulin 3 ; Cai, Hongling 4 ; Zhang, Dong 4   VIAFID ORCID Logo  ; Huang, Guofu 2 ; He, Xingdao 3 ; Wu, Xiaoshan 4 

 School of Physics, Nanjing University, Nanjing 210093, China; School of Testing and Optoelectronic Engineering, Nanchang Hangkong University, Nanchang 330063, China 
 School of Medical, Nanchang University, Nanchang 330031, China 
 School of Testing and Optoelectronic Engineering, Nanchang Hangkong University, Nanchang 330063, China 
 School of Physics, Nanjing University, Nanjing 210093, China 
First page
30
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20754418
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2761098421
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.