Abstract

Context

Cnidium monnieri Cusson (Apiaceae) has been used in traditional Asian medicine for thousands of years. Recent studies showed its active compound, osthole, had a good effect on osteoporosis. But there was no comprehensive analysis.

Objective

This meta-analysis evaluates the effects of osthole on osteoporotic rats and provides a basis for future clinical studies.

Methods

Chinese and English language databases (e.g., PubMed, Web of Science, Cochrane Library, Google Scholar, Embase, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, Weipu Chinese Sci-tech periodical full-text database, and Chinese BioMedical Literature Database) were searched from their establishment to February 2021. The effects of osthole on bone mineral density, osteoclast proliferation, and bone metabolism markers were compared with the effects of control treatments.

Results

To our knowledge, this is the first meta-analysis to evaluate osthole for the treatment of osteoporosis in rats. We included 13 randomized controlled studies conducted on osteoporotic rats. Osthole increased bone mineral density (standardized mean difference [SMD] = 3.08, 95% confidence interval [CI] = 2.08–4.09), the subgroup analysis showed that BMD significantly increased among rats in osthole <10 mg/kg/day and duration of osthole treatment >2 months. Osthole improved histomorphometric parameters and biomechanical parameters, also inhibited osteoclast proliferation and bone metabolism.

Conclusions

Osthole is an effective treatment for osteoporosis. It can promote bone formation and inhibit bone absorption.

Details

Title
Effects of osthole on osteoporotic rats: a systematic review and meta-analysis
Author
Wu, Bin 1 ; Xiu-Fang Zhu 1 ; Xiao-Qiang, Yang 1 ; Wei-Yi, Wang 2 ; Jian-Hua, Lu 3   VIAFID ORCID Logo 

1  The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China 
2  Department of Pneumology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China 
3  Department of Orthopaedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China 
Pages
1625-1634
Publication year
2022
Publication date
Dec 2022
Publisher
Taylor & Francis Ltd.
ISSN
13880209
e-ISSN
17445116
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/13880209.2022.2110267
ProQuest document ID
2761420864
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.