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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Monitoring changes in edema-associated intracranial pressure that complicates trauma or surgery would lead to improved outcomes. Implantable pressure sensors have been explored, but these sensors require post-surgical removal, leading to the risk of injury to brain tissue. The use of biodegradable implantable sensors would help to eliminate this risk. Here, we demonstrate a bioactive glass (BaG)-based hydration sensor. Fluorine (CaF2) containing BaG (BaG-F) was produced by adding 5, 10 or 20 wt.% of CaF2 to a BaG matrix using a melting manufacturing technique. The structure, morphology and electrical properties of the resulting constructs were evaluated to understand the physical and electrical behaviors of this BaG-based sensor. Synthesis process for the production of the BaG-F-based sensor was validated by assessing the structural and electrical properties. The structure was observed to be amorphous and dense, the porosity decreased and grain size increased with increasing CaF2 content in the BaG matrix. We demonstrated that this BaG-F chemical composition is highly sensitive to hydration, and that the electrical sensitivity (resistive–capacitive) is induced by hydration and reversed by dehydration. These properties make BaG-F suitable for use as a humidity sensor to monitor brain edema and, consequently, provide an alert for increased intracranial pressure.

Details

Title
A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications
Author
Gharbi, Amina 1 ; Ahmed Yahia Kallel 2   VIAFID ORCID Logo  ; Kanoun, Olfa 2   VIAFID ORCID Logo  ; Cheikhrouhou-Koubaa, Wissem 3   VIAFID ORCID Logo  ; Contag, Christopher H 4 ; Antoniac, Iulian 5   VIAFID ORCID Logo  ; Derbel, Nabil 6 ; Ashammakhi, Nureddin 4 

 CEM Lab, National Engineering School of Sfax, Sfax University, Sfax 3018, Tunisia; Technopole de Sfax. BP 275, LT2S Lab, Centre de Recherche en Numérique de Sfax, Sfax 3000, Tunisia 
 MST, Chair for Measurement and Sensor Technology, Technische Universittät Chemnitz, 09111 Chemnitz, Germany 
 Technopole de Sfax. BP 275, LT2S Lab, Centre de Recherche en Numérique de Sfax, Sfax 3000, Tunisia 
 Institute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME), Michigan State University, East Lansing, MI 48824, USA 
 SIM, Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Bucharest, Romania 
 CEM Lab, National Engineering School of Sfax, Sfax University, Sfax 3018, Tunisia 
First page
226
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
2072666X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2767264366
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.