Abstract

Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.

Details

Title
Building train carriages for ciliary transport: (IFT-)A complex task
Author
Gonçalves-Santos, Francisco 1 ; De-Castro, Maria J. G. 1 ; De-Castro, Ana R. G. 1 ; Dantas, Tiago J. 1 

 Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal (GRID:grid.5808.5) (ISNI:0000 0001 1503 7226); Universidade do Porto, IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal (GRID:grid.5808.5) (ISNI:0000 0001 1503 7226) 
Pages
91
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
23993642
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2768595723
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.