Abstract

Background

Elevated levels of S-100B in serum are increasingly considered a potential biochemical marker of nervous system damage. To our knowledge, limited number of research studies have tested the serum S-100B protein levels in children with epilepsy. The objective of our study is to measure the serum levels of S-100B protein in pediatric cases with epilepsy.

Results

The mean serum concentration of S-100B protein was 0.135 ± 0.014 mg/L in the patient group and 0.082 ± 0.018 mg/L in the control group. The patients showed significantly high S-100B protein levels compared with healthy controls (P < 0.001).

Conclusion

Our data suggest that increased S-100B protein levels in the serum potentially indicate neuronal damage in the brains of children with epilepsy.

Details

Title
Serum protein S-100B as a novel biomarker of diagnosis and prognosis of childhood epilepsy
Author
Khamis, Mohamed 1   VIAFID ORCID Logo  ; Din, Nahed Salah El 1 ; Nada, Maha Ali 1 ; Afifi, Hossam El Din Mahmoud 1 

1  Ain Shams University, Neurology, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570) 
Pages
19
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
ISSN
11101083
e-ISSN
16878329
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s41983-023-00605-x
ProQuest document ID
2773496455
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.