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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Gastric cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. Helicobacter pylori (H. pylori) is one of the main risk factors for this type of neoplasia. Carcinogenetic mechanisms associated with H. pylori are based, on the one hand, on the onset of chronic inflammation and, on the other hand, on bacterial-specific virulence factors that can damage the DNA of gastric epithelial cells and promote genomic instability. Here, we review and discuss the major pathogenetic mechanisms by which H. pylori infection contributes to the onset and development of gastric cancer.

Details

Title
Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms
Author
Salvatori, Silvia 1   VIAFID ORCID Logo  ; Marafini, Irene 1 ; Laudisi, Federica 2   VIAFID ORCID Logo  ; Monteleone, Giovanni 1   VIAFID ORCID Logo  ; Stolfi, Carmine 2   VIAFID ORCID Logo 

 Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; Gastroenterology Unit, Policlinico Universitario Tor Vergata, 00133 Rome, Italy 
 Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy 
First page
2895
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2774912850
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.