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Copyright © 2023 Rajinder Singh et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Background. Ficus benjamina L. is an evergreen tree, native to Southeast Asia, and often known as a weeping fig. Its latex and fruit extracts are used by indigenous cultures to cure skin conditions, inflammation, vomiting, leprosy, malaria, and nasal ailments. The aqueous extract of the figs of Ficus benjamina L. has various therapeutic values, including biological activities on the central nervous system. Materials and Methods. The extract of the dried figs of Ficus benjamina L. (FBE) was prepared by defatting with petroleum ether for 16 h followed by soxhelation with 70% methanol (1 : 10 w/v) for 24 h, and standardization of the extract was carried out using HPLC with 5-HT as a standard. Electroconvulsions were induced by the maximal electroshock model, and chemoconvulsions were induced by picrotoxin. Results. The HPLC chromatogram of the Ficus benjamina L. extract showed an absorption peak with a retention time of 1.797 min, similar to that observed with standard serotonin (5-HT) solution. In the maximal electroshock model, FBE significantly reduced the duration of the tonic hind limb extensor and extensor-to-flexor ratio (E/F ratio) in a dose-dependent manner. Moreover, in the picrotoxin-induced seizure model, FBE increased the seizure latency and decreased the duration of tonic-clonic convulsions dose-dependently. We confirmed the anticonvulsant activity of the FBE extract as it attenuated both maximal electroshock and picrotoxin-induced convulsions. Conclusion. The in vivo studies revealed that the Ficus extract was found to protect the animals in electroshock-induced and picrotoxin-induced convulsions.

Details

Title
Exploring the Anticonvulsant Activity of Aqueous Extracts of Ficus benjamina L. Figs in Experimentally Induced Convulsions
Author
Singh, Rajinder 1 ; Khalid, Mohammad 2   VIAFID ORCID Logo  ; Batra, Nikhil 3 ; Biswas, Partha 4   VIAFID ORCID Logo  ; Singh, Lovedeep 5   VIAFID ORCID Logo  ; Bhatti, Rajbir 1   VIAFID ORCID Logo 

 Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India 
 Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia 
 Department of General Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar Deemed to be University, Ambala, India 
 Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh 
 University Institute of Pharma Sciences, Chandigarh University, Mohali 140413, Punjab, India 
Editor
Romina Alina Marc Vlaic
Publication year
2023
Publication date
2023
Publisher
John Wiley & Sons, Inc.
ISSN
20909063
e-ISSN
20909071
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2775460526
Copyright
Copyright © 2023 Rajinder Singh et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/