Abstract

Background

Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction. However, abnormality in which epidermal function contributes to inflammaging is not clear.

Objective

We delineated the correlation of epidermal functions with circulating levels of proinflammatory cytokines in the elderly.

Methods

Blood sample was collected from a total of 255 participants aged ≥ 65 years. Epidermal biophysical properties were measured on the left forearm and the right shin. Serum cytokine levels were measured by Multiplex Luminex Assays.

Results

Neither skin surface pH nor transepidermal water loss rates (TEWL) correlated with serum cytokine levels except TEWL on the right shin for TNFa (p < 0.05). In contrast, stratum corneum hydration levels on both the forearm and the shin correlated negatively with serum cytokine levels (p < 0.05).

Conclusion

Reduced stratum corneum hydration likely contributes to inflammaging.

Details

Title
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging
Author
Yang, Bin; Lv, Chengzhi; Li, Ye; Wang, Zhen; Yoon, Kim; Luo, Wenhai; Elias, Peter M; Mao-Qiang, Man
Pages
1-5
Section
Correspondence
Publication year
2023
Publication date
2023
Publisher
BioMed Central
e-ISSN
1742-4933
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2777784215
Copyright
© 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.