Full text

Turn on search term navigation

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The essential oil of Achillea setacea was isolated by hydrodistillation and characterized by GC-MS. The antioxidant and antimicrobial activity of Achillea setacea essential oil was evaluated, as well as its biocompatibility (LDH and MTT methods). DPPH, FRAP, and CUPRAC methods were applied for antioxidant activity evaluation, while qualitative and quantitative assays (inhibition zone diameter, minimum inhibitory concentration, and minimum fungicidal concentration), NO release (by nitrite concentration determination), and microbial adhesion capacity to the inert substrate (the biofilm microtiter method) were used to investigate the antimicrobial potential. A total of 52 compounds were identified by GC-MS in A. setacea essential oil, representing 97.43% of the total area. The major constituents were borneol (32.97%), 1,8-cineole (14.94%), camphor (10.13%), artemisia ketone (4.70%), α-terpineol (3.23%), and γ-eudesmol (3.23%). With MICs ranging from 0.78 to 30 μg/mL, the A. setacea essential oil proved to inhibit the microbial adhesion and induce the NO release. To the best of our knowledge, the present study reports for the first time the antimicrobial activity of A. setacea EO against clinically and biotechnologically important microbial strains, such as Shigella flexneri, Listeria ivanovii, L. innocua, Saccharomyces cerevisiae, Candida glabrata, Aspergillus niger, Rhizopus nigricans, Cladosporium cladosporioides, and Alternaria alternata, demonstrating its antimicrobial applications beyond the clinical field.

Details

Title
Chemical and Biological Studies of Achillea setacea Herba Essential Oil—First Report on Some Antimicrobial and Antipathogenic Features
Author
Marinas, Ioana Cristina 1   VIAFID ORCID Logo  ; Oprea, Eliza 2   VIAFID ORCID Logo  ; Gaboreanu, Diana Madalina 2 ; Pircalabioru, Gratiela Gradisteanu 3 ; Buleandra, Mihaela 4 ; Nagoda, Eugenia 5 ; Badea, Irinel Adriana 4 ; Chifiriuc, Mariana Carmen 6   VIAFID ORCID Logo 

 Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, 050095 Bucharest, Romania; Research and Development Department of S.C. Sanimed International Impex SRL, Șos. București-Giurgiu (DN5), No. 6, 087040 Călugăreni, Romania 
 Faculty of Biology, Department of Botany and Microbiology, University of Bucharest, 1-3 Portocalilor Way, 060101 Bucharest, Romania 
 Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, 050095 Bucharest, Romania; Academy of Romanian Scientists, 3rd Ilfov Street, 051157 Bucharest, Romania 
 Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, 90-92 Panduri Street, 050663 Bucharest, Romania 
 Garden “D. Brandza”, University of Bucharest, 32 Sos. Cotroceni, 060114 Bucharest, Romania 
 Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, 050095 Bucharest, Romania; Research and Development Department of S.C. Sanimed International Impex SRL, Șos. București-Giurgiu (DN5), No. 6, 087040 Călugăreni, Romania; The Romanian Academy, Biological Sciences Division, Calea Victoriei 125, 010071 Bucharest, Romania 
First page
371
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20796382
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2779423272
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.