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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimensional natural hydrophilic atmosphere pivotal for cell survival and new tissue formation. Thus, hydrogel-based cell distribution and drug administration have evolved as possible options for bone tissue engineering and regeneration. In this context, nanogels or nanohydrogels, created by cross-linking three-dimensional polymer networks, either physically or chemically, with high biocompatibility and mechanical properties were introduced as promising drug delivery systems. The present review highlights the potential of hydrogels and nanopolymers in the field of craniofacial tissue engineering and bone regeneration.

Details

Title
Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review
Author
Bashir, Maha H 1 ; Korany, Nahed S 1 ; Farag, Dina B E 1 ; Abbass, Marwa M S 2   VIAFID ORCID Logo  ; Ezzat, Bassant A 1 ; Hegazy, Radwa H 1 ; Dörfer, Christof E 3   VIAFID ORCID Logo  ; Fawzy El-Sayed, Karim M 4   VIAFID ORCID Logo 

 Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, Egypt 
 Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, Egypt; Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11553, Egypt 
 Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 24105 Kiel, Germany 
 Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11553, Egypt; Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 24105 Kiel, Germany; Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo 11553, Egypt 
First page
205
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
2218273X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2779465380
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.