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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Bunyamwera virus is the prototype of the Bunyamwera serogroup, which belongs to the order Bunyavirales of the Orthobunyavirus genus in the Peribunyaviridae family. Bunyamwera is a negative-sense RNA virus composed of three segments S, M, and L. Genetic recombination is possible between members of this order as it is already documented. Additionally, it can lead to pathogenic or host range improvement, if it occurs with viruses of public health and agricultural importance such as Rift Valley fever virus and Crimea–Congo hemorrhagic fever virus. Here, we characterize five African Orthobunyavirus viruses from different geographical regions. Our results suggest that the five newly characterized strains are identified as Bunyamwera virus strains. Furthermore, two of the five strains sequenced in this study are recombinant strains, as fragments of their segments are carried by Ngari and Bunyamwera strains. Further investigations are needed to understand the functional impact of these recombinations.

Details

Title
Whole Genome Sequencing Analysis of African Orthobunyavirus Isolates Reveals Naturally Interspecies Segments Recombinations between Bunyamwera and Ngari Viruses
Author
Mhamadi, Moufid 1   VIAFID ORCID Logo  ; Dieng, Idrissa 2   VIAFID ORCID Logo  ; Dolgova, Anna S 3   VIAFID ORCID Logo  ; Touré, Cheikh Talibouya 2   VIAFID ORCID Logo  ; Ndiaye, Mignane 2   VIAFID ORCID Logo  ; Moussa Moïse Diagne 2   VIAFID ORCID Logo  ; Babacar Faye 4 ; Gladkikh, Anna S 3   VIAFID ORCID Logo  ; Dedkov, Vladimir G 3   VIAFID ORCID Logo  ; Sall, Amadou Alpha 2 ; Ousmane Faye 2 ; Oumar Faye 2   VIAFID ORCID Logo 

 Virology Department, Institut Pasteur de Dakar, Dakar 12900, Senegal; Parasitology Department, Université Cheikh Anta Diop de Dakar, Dakar 10700, Senegal 
 Virology Department, Institut Pasteur de Dakar, Dakar 12900, Senegal 
 Saint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia 
 Parasitology Department, Université Cheikh Anta Diop de Dakar, Dakar 10700, Senegal 
First page
550
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19994915
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2779700694
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.