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Abstract
Under conventional and silica-supported Muffle furnace methods, water-soluble substituted trimeric triaryl pyridinium cations with various inorganic counter anions are synthesized. The solvent-free synthesis method is superior to the conventional method in terms of non-toxicity, quicker reaction times, ease of workup, and higher yields. Trimeric substituted pyridinium salts acted as excellent catalytic responses for the preparation of Gem-bisamide derivatives compared with available literature. To evaluate the molecular docking, benzyl/4-nitrobenzyl substituted triaryl pyridinium salt compounds with VEGFR-2 kinase were used with H-bonds, π–π stacking, salt bridges, and hydrophobic contacts. The results showed that the VEGFR-2 kinase protein had the most potent inhibitory activity. Intriguingly, the compound [NBTAPy]PF6- had a strongly binds to VEGFR-2 kinase and controlled its activity in cancer treatment and prevention.
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1 Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Department of Chemistry, Avadi, Chennai, India
2 Dwaraka Doss Goverdhan Doss Vaishnav College, Department of Biochemistry, Chennai, India (GRID:grid.413015.2) (ISNI:0000 0004 0505 215X)
3 Mohamed Sathak College of Arts & Science, Department of Chemistry, Sholinganallur, Chennai, India (GRID:grid.413015.2)
4 Periyar University Centre for Post Graduate and Research Studies, Department of Physics, Dharmapuri, India (GRID:grid.412490.a) (ISNI:0000 0004 0538 1156)
5 Saveetha School of Engineering, (SIMATS), Department of Physics, Thandalam, Chennai, India (GRID:grid.412431.1) (ISNI:0000 0004 0444 045X)
6 University of Warith Al-Anbiyaa, College of Medicine, Karbala, Iraq (GRID:grid.513648.d) (ISNI:0000 0004 7642 4328)
7 Al-Mustaqbal University College, Radiological Techniques Department, Hillah, Babylon, Iraq (GRID:grid.517728.e) (ISNI:0000 0004 9360 4144)
8 University of Misan, College of Agriculture, Al-Amara, Iraq (GRID:grid.449919.8) (ISNI:0000 0004 1788 7058)
9 University of Basrah, Department of Chemistry, Faculty of Science, Basrah, Iraq (GRID:grid.411576.0) (ISNI:0000 0001 0661 9929)
10 University of Technology, Applied Science Department, Baghdad, Iraq (GRID:grid.444967.c) (ISNI:0000 0004 0618 8761)
11 Universiti Putra Malaysia, Catalysis Science and Technology Research Centre, Faculty of Science, Serdang, Malaysia (GRID:grid.11142.37) (ISNI:0000 0001 2231 800X); University Malaysia Sabah, Faculty of Science and Natural Resources, Kota Kinabalu, Sabah, Malaysia (GRID:grid.265727.3) (ISNI:0000 0001 0417 0814)