Abstract

Multiple myeloma (MM) patients with t(11;14) present unique biological features and their prognosis is not well established. We report a retrospective study of 591 MM patients, 17.3% of whom had t(11;14). It was designed to determine the prognostic impact of this abnormality and the effect of novel agents on the response and outcomes. Three groups were established based on their cytogenetics: (1) t(11;14); (2) high-risk chromosomal abnormalities; and (3) standard risk (SR). After 80.1 months (1.2–273.8 months) of follow-up, no differences were observed in overall survival (OS) between the t(11;14) and SR groups (75.8 vs. 87.2 months; P = 0.438). Treatment of MM t(11;14) with novel agents did not improve their overall response rate (ORR) or complete response (CR) compared with those who received conventional therapy (ORR: 87.2 vs. 79.5%, P = 0.336; CR: 23.4 vs. 12.8%, P = 0.215). This effect translated into a similar PFS (39.6 vs. 30.0 months; P = 0.450) and OS (107.6 vs. 75.7 months; P = 0.175). In summary, MM t(11;14) patients did not benefit from the introduction of novel agents as much as SR patients did, indicating that other therapies are needed to improve their outcomes.

Details

Title
Multiple myeloma with t(11;14): impact of novel agents on outcome
Author
Puertas, Borja 1 ; González-Calle, Verónica 1 ; Sobejano-Fuertes, Eduardo 2 ; Escalante, Fernando 3 ; Rey-Bua, Beatriz 1 ; Padilla, Irene 3 ; García-Sanz, Ramón 1   VIAFID ORCID Logo  ; Puig, Noemi 1 ; Gutiérrez, Norma C. 1 ; Mateos, María-Victoria 1   VIAFID ORCID Logo 

1  University Hospital of Salamanca/IBSAL/Cancer Research Center-IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain (GRID:grid.510933.d) (ISNI:0000 0004 8339 0058) 
2  University Hospital Dr. José Molina Orosa, Lanzarote, Canary Islands, Department of Hematology, Palmas, Spain (GRID:grid.510933.d) 
3  University Hospital of León, Department of Hematology, León, Spain (GRID:grid.411969.2) (ISNI:0000 0000 9516 4411) 
Pages
40
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
e-ISSN
20445385
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41408-023-00807-9
ProQuest document ID
2788271737
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.