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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Due to the importance of not mistaking when determining the brain death (BD) diagnostic, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system. Methods: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative parameters from the ICP waveforms, such as the P2/P1 ratio, time-to-peak (TTP) and pulse amplitude (AMP) were extracted and analyzed comparing BD patients and health subjects. Results: Fifteen patients were included, and 6172 waveforms were analyzed. ICP waveforms presented substantial differences amidst BD patients when compared to the control group, especially AMP, which had lower values in patients diagnosed with BD (p < 0.0001) and the TTP median (p < 0.00001), but no significance was found for the P2/P1 ratio (p = 0.8). The area under curve for combination of parameters on the BD prediction was 0.77. Conclusions: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.

Details

Title
Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol
Author
Mylena Miki Lopes Ideta 1 ; Louise Makarem Oliveira 2 ; Daniel Buzaglo Gonçalves 1   VIAFID ORCID Logo  ; Mylla Christie de Oliveira Paschoalino 1 ; Nise Alessandra de Carvalho Sousa 1 ; Della Coletta, Marcus Vinicius 3 ; Paiva, Wellingson 4 ; Brasil, Sérgio 4 ; Robson Luís Oliveira de Amorim 5   VIAFID ORCID Logo 

 Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil 
 Department of Neurology, University of São Paulo, Ribeirão Preto 14049, ZIP, Brazil 
 Department of Neurology, Amazonas State University, Manaus 69005, ZIP, Brazil 
 Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo 01246, ZIP, Brazil 
 Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil; Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo 01246, ZIP, Brazil 
First page
401
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20763425
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2791595145
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.