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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Methods: Seventy patients were included in this study. Blood samples were taken from the patients before and after transfusion. Total thiol, native thiol, disulfide, disulfide/native thiol percentage ratio, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and ferroxidase levels were determined. Additionally, undepleted thiol level (UTL) was determined as a new parameter associated with organ damage. Results: After transfusion, the levels of native thiol, total thiol, disulfide, TAS, ferroxidase, and TOS were higher, while the IMA levels and disulfide/native thiol percent ratio were lower. Significant correlations were found between antioxidant and oxidant tests before and after transfusion. Additionally, a negative correlation was found between the TOS and UTL levels of the patients measured before the transfusion. Conclusion: In the present study, transfusion therapy increased both oxidation and the antioxidant levels. In addition, the term UTL has been introduced as a parameter that enables the determination of the oxidation level that may cause potential organ damage in transfusion-dependent thalassemia patients.

Details

Title
A New Perspective for Potential Organ Damage Due to Iron-Mediated Oxidation in Thalassemia Major Patients
Author
Eren, Funda 1 ; Ayça Koca Yozgat 2 ; Oğuz, Esra Firat 1 ; Neşelioğlu, Salim 3 ; Firat, Rıdvan 1 ; Dilek Gürlek Gökçebay 2 ; Yarali, Hüsniye Neşe 2 ; Özbek, Namık Yaşar 2 ; Özcan Erel 3 

 Department of Medical Biochemistry Laboratory, Ankara Bilkent City Hospital, 06800 Ankara, Turkey 
 Department of Pediatric Hematology and Oncology, Ankara Bilkent City Hospital, 06800 Ankara, Turkey 
 Department of Medical Biochemistry, Yıldırım Beyazıt University, 06010 Ankara, Turkey 
First page
2422
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2791652087
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.