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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Patients diagnosed with the primary headache disorder known as cluster headache (CH) commonly report that their headache attacks occur in patterns of both circadian and seasonal rhythmicity. Vitamin D is essential for a variety of bodily functions and vitamin D levels are largely regulated by daylight exposure in connection with seasonal variation. For this Sweden-based study, the association between CH and three single-nucleotide polymorphisms in the vitamin D receptor gene, rs2228570, rs1544410, and rs731236, were investigated, as well as CH bouts and trigger factors in relation to seasonal and weather changes. Over 600 study participants with CH and 600 controls were genotyped for rs2228570, and genotyping results for rs1544410 and rs731236 were obtained from a previous genome-wide association study. The genotyping results were combined in a meta-analysis, with data from a Greek study. No significant association was found between rs2228570 and CH or the CH subtype in Sweden, nor did the meta-analysis show significant results for any of the three markers. The most common period of the year to experience CH bouts in Sweden was autumn, and conditions linked to weather or weather changes were also identified as potential triggers for CH bouts for a quarter of the responders who reported bout triggers. Though we cannot rule out vitamin D involvement in CH, this study does not indicate any connection between CH and the three vitamin D receptor gene markers.

Details

Title
Investigating Vitamin D Receptor Genetic Markers in a Cluster Headache Meta-Analysis
Author
Olofsgård, Felicia Jennysdotter 1   VIAFID ORCID Logo  ; Ran, Caroline 1   VIAFID ORCID Logo  ; Qin, Yuyan 1 ; Fourier, Carmen 1 ; Sjöstrand, Christina 2 ; Waldenlind, Elisabet 3 ; Steinberg, Anna 3 ; Belin, Andrea Carmine 1   VIAFID ORCID Logo 

 Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden 
 Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Neurology, Danderyd Hospital, 182 88 Stockholm, Sweden 
 Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Neurology, Karolinska University Hospital, 171 64 Stockholm, Sweden 
First page
5950
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2791654466
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.