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Abstract
This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively. Demographic and ophthalmological data, ET-1 concentrations, LDI (before and 1, 10, and 20 min after cold stimulation), and nailfold capillaroscopy findings were evaluated. The ET-1 blood level was 65% higher in the LTDH (2.27 ± 1.46 pg/ml) than in the HTDH (1.37 ± 0.57 pg/ml; p = 0.03) group. Moreover, there was a statistically significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r = −0.45, p = 0.02). Blood flow measurements 10 and 20 min after cold stimulation were lower in the LTDH group than in the HTDH group (p < 0.01). Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction as estimated by LDI than those with higher IOPs. These findings suggest that distinct underlying mechanisms may be involved in patients developing DH within different IOP ranges.
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1 Federal University of São Paulo, Department of Ophthalmology, São Paulo, Brazil (GRID:grid.411249.b) (ISNI:0000 0001 0514 7202)
2 Federal University of Sao Paulo, Rheumatology Division, Sao Paulo, Brazil (GRID:grid.411249.b) (ISNI:0000 0001 0514 7202)
3 Federal University of São Paulo, Department of Ophthalmology, São Paulo, Brazil (GRID:grid.411249.b) (ISNI:0000 0001 0514 7202); Hospital Medicina dos Olhos, Glaucoma Unit, Osasco, Brazil (GRID:grid.411249.b)
4 Hospital Medicina dos Olhos, Glaucoma Unit, Osasco, Brazil (GRID:grid.411249.b)
5 Mayo Clinic, Department of Ophthalmology, Jacksonville, USA (GRID:grid.417467.7) (ISNI:0000 0004 0443 9942)
6 New York Eye and Ear Infirmary of Mount Sinai, Einhorn Clinical Research Center, New York, USA (GRID:grid.420243.3) (ISNI:0000 0001 0002 2427)
7 Federal University of São Paulo, Department of Ophthalmology, São Paulo, Brazil (GRID:grid.411249.b) (ISNI:0000 0001 0514 7202); Ver Mais Oftalmologia, Centro de Estudos Alcides Hirai, Vinhedo, São Paulo, Brazil (GRID:grid.411249.b)
8 Federal University of São Paulo, Department of Ophthalmology, São Paulo, Brazil (GRID:grid.411249.b) (ISNI:0000 0001 0514 7202); Hospital Medicina dos Olhos, Glaucoma Unit, Osasco, Brazil (GRID:grid.411249.b); Mayo Clinic, Department of Ophthalmology, Jacksonville, USA (GRID:grid.417467.7) (ISNI:0000 0004 0443 9942)