Abstract

Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery

Details

Title
Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
Author
Goon, Peter 1   VIAFID ORCID Logo  ; Sauzet, Odile 2 ; Schuermann, Matthias 3 ; Oppel, Felix 3   VIAFID ORCID Logo  ; Shao, SenYao 3 ; Scholtz, Lars-Uwe 3 ; Sudhoff, Holger 3 ; Goerner, Martin 4 

1  National University Health System, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, and Departments of Dermatology & Otolaryngology, Singapore, Singapore (GRID:grid.410759.e) (ISNI:0000 0004 0451 6143) 
2  University of Bielefeld, Bielefeld School of Public Health and Department of Business Administration and Economics, Bielefeld, Germany (GRID:grid.7491.b) (ISNI:0000 0001 0944 9128) 
3  University Hospital OWL of Bielefeld University, University Dept of Otolaryngology, Campus Klinikum Bielefeld Mitte, Bielefeld, Germany (GRID:grid.7491.b) (ISNI:0000 0001 0944 9128) 
4  University Hospital OWL of Bielefeld University, Dept of Haematology, Oncology and Palliative Medicine, Campus Klinikum Bielefeld Mitte, Bielefeld, Germany (GRID:grid.7491.b) (ISNI:0000 0001 0944 9128) 
Pages
49
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20590105
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41541-023-00644-8
ProQuest document ID
2793846934
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.