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Abstract
In this study, it was aimed to introduce a transdermal drug delivery system with dissolving microneedles (DMNs) based on gelatin (GEL) and sodium carboxymethyl cellulose (NaCMC) for lidocaine hydrochloride (LidoHCl) delivery. Different ratios of GEL and NaCMC were mixed, loaded with an active agent of LidoHCl, and treated with glutaraldehyde (GTA) as a crosslinker agent. Prepared hydrogels were cast into a silicon mold. Hereby, microneedles (MNs) with 500 µm height, 35° needle angle, 40-µm tip radius, and 960-µm tip-to-tip distance were fabricated. Samples containing LidoHCl 40%, GEL/NaCMC 5:1 (wt/wt), and polymer/GTA ratio 3.1 (wt/wt) showed the highest drug release ability (t < 10 min) with proper mechanical properties in comparison with other samples. Due to the drug release in a short time (fewer than 10 min), this drug delivery system can be used for rapid local anesthesia for pain relief as well as before minor skin surgeries.
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Details
1 Islamic Azad University, South Tehran Branch, Department of Polymer Engineering, Faculty of Engineering, Tehran, Iran (GRID:grid.472433.5) (ISNI:0000 0004 0612 0652)
2 Islamic Azad University, South Tehran Branch, Department of Polymer and Textile, Tehran, Iran (GRID:grid.472433.5) (ISNI:0000 0004 0612 0652)
3 Islamic Azad University, South Tehran Branch, Department of Polymer Engineering, Faculty of Engineering, Tehran, Iran (GRID:grid.472433.5) (ISNI:0000 0004 0612 0652); Iran Polymer and Petrochemical Institute (IPPI), Department of Polymer Processing, Tehran, Iran (GRID:grid.419412.b) (ISNI:0000 0001 1016 0356)
4 Tehran Medical Sciences Branch Islamic Azad University, Department of Medical, Tehran, Iran (GRID:grid.411463.5) (ISNI:0000 0001 0706 2472)